PHCCC

O\N=C1/[C@H]2C[C@]2(OC3=CC=CC=C13)C(=O)NC4=CC=CC=C4

InChIKey=FPXPIEZPAXSELW-REIIWYCASA-N

InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15-/t13-,17-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	1
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Potency
Metabotropic glutamate receptor 6 6 Target ID: CHEMBL3842 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18593581	Positive Allosteric Modulator 179	4.8 null [pEC50]
Metabotropic glutamate receptor 4 5 Target ID: CHEMBL2736 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14573382 \| https://www.ncbi.nlm.nih.gov/pubmed/23098651	Positive Allosteric Modulator 179	3.8 µM [EC50]
Metabotropic glutamate receptor 1 25 Target ID: CHEMBL3772 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14573382	Antagonist 2778	3.4 µM [IC50]
Metabotropic glutamate receptor 4 5 Target ID: CHEMBL2736 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14593202	Positive Allosteric Modulator 179	4.5 null [pEC50]
Metabotropic glutamate receptor 6 6 Target ID: CHEMBL4573 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18593581	Positive Allosteric Modulator 179	4.8 null [pEC50]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:20:22 GMT 2023` Edited by `admin` on `Sat Dec 16 18:20:22 GMT 2023`
Record UNII	875PGG7NBA
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

PHCCC

Common Name

English

BENZO(B)CYCLOPROPA(E)PYRAN-1A(1H)-CARBOXAMIDE, 7,7A-DIHYDRO-7-(HYDROXYIMINO)-N-PHENYL-

Systematic Name

English

N-PHENYL-7-(HYDROXYIMINO)CYCLOPROPA(B)CHROMEN-1A-CARBOXAMIDE

Systematic Name

English

BENZO(B)CYCLOPROPA(E)PYRAN-1A(1H)-CARBOXAMIDE, 7,7A-DIHYDRO-7-(HYDROXYIMINO)-N-PHENYL-, (E)-

Systematic Name

English

7,7A-DIHYDRO-7-(HYDROXYIMINO)-N-PHENYLBENZO(B)CYCLOPROPA(E)PYRAN-1A(1H)-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

CAS

179068-02-1