PD-173952

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H21Cl2N5O2
Molecular Weight	482.362
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=O)C(=CC2=C1N=C(NC3=CC=C(C=C3)N4CCOCC4)N=C2)C5=C(Cl)C=CC=C5Cl

InChI

InChIKey=XZEJMVDCQZRHLN-UHFFFAOYSA-N

InChI=1S/C24H21Cl2N5O2/c1-30-22-15(13-18(23(30)32)21-19(25)3-2-4-20(21)26)14-27-24(29-22)28-16-5-7-17(8-6-16)31-9-11-33-12-10-31/h2-8,13-14H,9-12H2,1H3,(H,27,28,29)

HIDE SMILES / InChI

Molecular Formula	C24H21Cl2N5O2
Molecular Weight	482.362
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tyrosine-protein kinase SRC 19 Target ID: CHEMBL267 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10974196	Inhibitor 8504		8.35 nM [IC50]
Bcr/Abl fusion protein 21 Target ID: CHEMBL2096618 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12200668	Inhibitor 8504

Substance Class	Chemical Created by `admin` on `Wed Apr 02 05:28:38 GMT 2025` Edited by `admin` on `Wed Apr 02 05:28:38 GMT 2025`
Record UNII	85GA4ESY8J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PD-173952

Code

English

PD173952

Preferred Name

English

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-8-methyl-2-[[4-(4-morpholinyl)phenyl]amino]-

Systematic Name

English

6-(2,6-BIS(CHLORANYL)PHENYL)-8-METHYL-2-((4-MORPHOLIN-4-YLPHENYL)AMINO)PYRIDO(2,3-D)PYRIMIDIN-7-ONE

Systematic Name

English

6-(2,6-dichlorophenyl)-8-methyl-2-[(4-morpholin-4-ylphenyl)amino]pyrido[6,5-d]pyrimidin-7-one

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID00416167

Created by admin on Wed Apr 02 05:28:38 GMT 2025 , Edited by admin on Wed Apr 02 05:28:38 GMT 2025

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FDA UNII

85GA4ESY8J

Created by admin on Wed Apr 02 05:28:38 GMT 2025 , Edited by admin on Wed Apr 02 05:28:38 GMT 2025

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CAS

305820-75-1

Created by admin on Wed Apr 02 05:28:38 GMT 2025 , Edited by admin on Wed Apr 02 05:28:38 GMT 2025

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PUBCHEM

5328733

Created by admin on Wed Apr 02 05:28:38 GMT 2025 , Edited by admin on Wed Apr 02 05:28:38 GMT 2025

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