N,N-DIETHYLETHYLENEDIAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H16N2
Molecular Weight	116.2046
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCN

InChI

InChIKey=UDGSVBYJWHOHNN-UHFFFAOYSA-N

InChI=1S/C6H16N2/c1-3-8(4-2)6-5-7/h3-7H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C6H16N2
Molecular Weight	116.2046
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10773085 | https://www.ncbi.nlm.nih.gov/pubmed/23927458

N,N-Diethylethylenediamine is used in the oxidative amidation of hydrogen phosphonate diesters in the synthesis of oligonucleotides. N,N-diethylethylenediamine was used to develop melanin targeted PET and single-photon emission computed tomography (SPECT) imaging agents for melanoma.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Melanoma 88 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23927458 https://www.ncbi.nlm.nih.gov/pubmed/25699145	Diagnostic		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
trans-Bis(N,N-diethyl-ethylenediamine)-nickel(II) dibromide.	2010-12-08	21522568
Equilibrium and kinetic investigations of the interaction of model platinum(II) complex with DNA constituents in reference to the antitumour activity: complex-formation reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with ligands of biological significance and displacement reactions of DNA constituents.	2009	19696935
Benzamides as melanotropic carriers for radioisotopes, metals, cytotoxic agents and as enzyme inhibitors.	2009	19519383
The prince and the pauper. A tale of anticancer targeted agents.	2008-10-23	18947424
Antiproliferative effects on human tumor cells and rat aortic smooth muscular cells of 2,3-heteroarylmaleimides and heterofused imides.	2008-02-15	18061459
Stability-indicating methods for determination of tiapride in pure form, pharmaceutical preparation, and human plasma.	2008-01-16	18193732
Di-μ-thio-cyanato-bis-({2,4-dichloro-6-[2-(diethyl-amino)ethyl-imino-meth-yl]phenolato}copper(II)).	2007-12-18	21200565
Tubular cationized pullulan hydrogels as local reservoirs for plasmid DNA.	2007-12-01	17559120
Synthesis and antimalarial properties of new chloro-9H-xanthones with an aminoalkyl side chain.	2007-07	17638332
Polyamine-substituted gadolinium chelates: a new class of intracellular contrast agents for magnetic resonance imaging of tumors.	2007-01-11	17201417
Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds.	2006-03	16442188
Antisense knockdown of cyclin E does not affect the midblastula transition in Xenopus laevis embryos.	2005-10	16131839
Distance and affinity dependence of triplex-induced recombination.	2005-03-15	15751961
Alkylating benzamides with melanoma cytotoxicity.	2004-10	15457090
Synthesis of novel biodegradable cationic polymer: N,N-diethylethylenediamine polyurethane as a gene carrier.	2004-09-14	15360307
Platelet adhesive resistance of polyurethane surface grafted with zwitterions of sulfobetaine.	2004-07-01	15261019
Design of amine-modified graft polyesters for effective gene delivery using DNA-loaded nanoparticles.	2004-06	15212155
Liquid chromatographic determination of ethambutol in serum samples based on intramolecular excimer-forming fluorescence derivatization.	2004-03	15068293
Anionic carbonato and oxalato cobalt(III) nitrogen mustard complexes.	2004-02-21	15252524
Water-soluble polycationic dendrimers with a phosphoramidothioate backbone: preliminary studies of cytotoxicity and oligonucleotide/plasmid delivery in human cell culture.	2003	15000835
Unusually long-lived light-induced metastable state in a thermochromic copper(II) complex.	2002-08-07	12170790
Chromosome targeting at short polypurine sites by cationic triplex-forming oligonucleotides.	2001-10-19	11504712

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Preparation of N-(2-diethylaminoethyl)-4-fluorobenzamide (DAFBA): A solution of N,N-diethylethylenediamine (1.0 g, 8.6 mmol) in dichloromethane (10 mL) was added slowly to the reaction mixture.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:52:11 GMT 2025` Edited by `admin` on `Mon Mar 31 21:52:11 GMT 2025`
Record UNII	859V6OK12Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N,N-DIETHYLETHYLENEDIAMINE

Systematic Name

English

NSC-19675

Preferred Name

English

TIAPRIDE HYDROCHLORIDE IMPURITY C [EP IMPURITY]

Common Name

English

.BETA.-(DIETHYLAMINO)ETHYLAMINE

Systematic Name

English

N-(2-(N,N-DIETHYLAMINO)ETHYL)AMINE

Systematic Name

English

1,2-ETHANEDIAMINE, N1,N1-DIETHYL-

Systematic Name

English

N,N-DIETHYL-1,2-DIAMINOETHANE

Systematic Name

English

METOCLOPRAMIDE IMPURITY E [EP IMPURITY]

Common Name

English

N,N-DIETHYL-1,2-ETHYLENEDIAMINE

Systematic Name

English

N,N-DIETHYLETHANE-1,2-DIAMINE

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

202-844-7