TECTORIGENIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12O6
Molecular Weight	300.2629
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C(O)C2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1O

InChI

InChIKey=OBBCRPUNCUPUOS-UHFFFAOYSA-N

InChI=1S/C16H12O6/c1-21-16-11(18)6-12-13(15(16)20)14(19)10(7-22-12)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3

HIDE SMILES / InChI

Molecular Formula	C16H12O6
Molecular Weight	300.2629
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Isoflavones from the mangrove endophytic fungus Fusarium sp. (ZZF41).	2010-11	21213977
Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose.	2010-09-22	20734984
[Simultaneous determination of tectorigenin-7-O-xylosylglucosid, tectoridin and tectorigenin in flowers of Pueraria lobata by HPLC].	2010-09	21137344
Anti-proliferative and pro-apoptotic effects of tectorigenin on hepatic stellate cells.	2010-08-21	20712052
Tectorigenin inhibits the in vitro proliferation and enhances miR-338* expression of pulmonary fibroblasts in rats with idiopathic pulmonary fibrosis.	2010-08-19	20600766
[Effect of tectorigenin on MCP-1 and ICAM-1 mRNA expression in injured vascular endothelial cells].	2010-08	20931855
Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos.	2010-07-01	20627560
Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside.	2010-07	20354803
Quantitative analysis of two isoflavones in Pueraria lobata flowers from eleven Chinese provinces using high performance liquid chromatography.	2010-04-23	20416072
Antimutagenic and anti-oxidant activities of isoflavonoids from Belamcanda chinensis (L.) DC.	2010-02	20096370
Isolation and identification of urinary metabolites of kakkalide in rats.	2010-02	19910516
Tyrosinase inhibitory constituents from the stems of Maackia fauriei.	2010-01	19441007
Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells.	2009-12	19928832
Isolation and purification of isoflavonoids from Rhizoma Belamcandae by two-dimensional preparative high-performance liquid chromatography with column switch technology.	2009-10	19382246
[Studies on the isoflavonoids of Iris tectorum].	2009-09	20034214
Inhibitory activity of isoflavones of Pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia.	2009-06	20183278
Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry.	2009-03-13	18550076
Identification of key metabolites of tectorigenin in rat urine by HPLC-MS(n).	2009-02	18850580
New isoflavone glycosides from Iris spuria L. (Calizona) cultivated in Egypt.	2009-01	18791667
Tectorigenin inhibits IFN-gamma/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells.	2008-11	19023541
The rapid identification of isoflavonoids from Belamcanda chinensis by LC-NMR and LC-MS.	2008-10	18827388
Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea.	2008-09	18782027
Identification of the major metabolites of tectorigenin in rat bile by liquid chromatography combined with time-of-flight and ion trap tandem mass spectrometry.	2008-09	18668634
Cytotoxic effects of compounds from Iris tectorum on human cancer cell lines.	2008-07-23	18508214
Identification of metabolites of tectoridin in-vivo and in-vitro by liquid chromatography-tandem mass spectrometry.	2008-06	18498706
Development and validation of an HPLC method for quality control of Pueraria lobata flower.	2007-12	18067064
The relevance of estrogen receptor-beta expression to the antiproliferative effects observed with histone deacetylase inhibitors and phytoestrogens in prostate cancer treatment.	2007-10	17913855
Aldose reductase inhibitory effect by tectorigenin derivatives from Viola hondoensis.	2006-11-15	16870454
Estrogenic effect of main components kakkalide and tectoridin of Puerariae Flos and their metabolites.	2006-06	16755017
[Pharmacological potential of phytoestrogens in the treatment of prostate cancer].	2006-02	16237540
Cytoprotective effect of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, on oxidative stress induced by hydrogen peroxide.	2005-09-05	16102749
Tectorigenin and other phytochemicals extracted from leopard lily Belamcanda chinensis affect new and established targets for therapies in prostate cancer.	2005-08	15845653
Analysis of DNA in endometrial cancer cells treated with phyto-estrogenic compounds using comparative genomic hybridisation microarrays.	2005-05	15931582
Hepatoprotective effect of tectoridin and tectorigenin on tert-butyl hyperoxide-induced liver injury.	2005-04	15821336
Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines.	2005-03	15787436
Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro.	2004-12	15538285
Belamcanda chinensis and the thereof purified tectorigenin have selective estrogen receptor modulator activities.	2004-07	15330494
Passive cutaneous anaphylaxis-inhibitory action of tectorigenin, a metabolite of tectoridin by intestinal microflora.	2004-07	15256747
Hypoglycemic and anti-lipemic effects of the aqueous extract from Cissus sicyoides.	2004-06-08	15182373
Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis on carbon tetrachloride-induced hepatic injury in rats.	2004-02	15022720
Induction of growth hormone release by Pueraria thunbergiana BENTH.	2004-02	15002057
Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury.	2003-08	12895260
Anti-angiogenic and anti-tumor activities of isoflavonoids from the rhizomes of Belamcanda chinensis.	2003-07	12898416
Antiplatelet and anti-HIV constituents from Euchresta formosana.	2003-04	12713120
Study of substance changes in flowers of Pueraria thunbergiana Benth. during storage.	2003-03	12723934
Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana.	2002-06	12135104
Isoflavonoids from the rhizomes of Belamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues.	2002-06	12135102
Effects of naturally occurring isoflavones on prostaglandin E2 production.	2002-02	11859455
Interaction of phytoestrogens with estrogen receptors alpha and beta (II).	2002-01	11824555
[Studies on chemical constituents of Maackia amurensis Rupr. et. Maxim].	2001-06	12528507

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:13:33 GMT 2025` Edited by `admin` on `Mon Mar 31 21:13:33 GMT 2025`
Record UNII	855130H9CO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TECTORIGENIN

Common Name

English

K 251T

Preferred Name

English

4',5,7-TRIHYDROXY-6-METHOXYISOFLAVONE

Common Name

English

TECTORIGENIN [MI]

Common Name

English

5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-6-METHOXY-4H-1-BENZOPYRAN-4-ONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1745