Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C24H30ClFO5 |
Molecular Weight | 452.943 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 9 / 9 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@H](C)[C@H](C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]3(Cl)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C
InChI
InChIKey=ARPLCFGLEYFDCN-CDACMRRYSA-N
InChI=1S/C24H30ClFO5/c1-12-7-15-16-9-18(26)17-8-14(28)5-6-23(17,4)24(16,25)20(30)10-22(15,3)21(12)19(29)11-31-13(2)27/h5-6,8,12,15-16,18,20-21,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,20+,21-,22+,23+,24+/m1/s1
Molecular Formula | C24H30ClFO5 |
Molecular Weight | 452.943 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 9 / 9 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/22791998Curator's Comment: https://www.ncbi.nlm.nih.gov/pubmed/22798972
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22791998
Curator's Comment: https://www.ncbi.nlm.nih.gov/pubmed/22798972
Clocortolone (used in form of pivalate prodrug) is a topical glucocorticoid that was approved by FDA for the treatment of corticosteroid-responsive skin disorders. The drug exerts its anti-inflammatory action by binding to glucocorticoid receptor which results in regulation of the expression of proinflammatory cytokines and further antiproliferative, immunosuppressive, and initial vasoconstrictive effects.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P04150 Gene ID: 2908.0 Gene Symbol: NR3C1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/22798972 |
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Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | CLODERM Approved UseTopical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Launch Date1977 |
PubMed
Title | Date | PubMed |
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[Experiences with clocortolone in treating of skin diseases in hospital and ambulatory care]. | 1969 Sep 27 |
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[Clocortolone (Cl 68) versus fluocinolone, a double-blind, randomized lateral comparison]. | 1973 Jul |
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Clocortolone, a new topical steroid in dermatoses. | 1973 Mar 24 |
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[Human-pharmacokinetic Studies on Penetration Kinetics of a 6 alpha-Fluoro-9 alpha-chloro-16 alpha-methyl-delta 1,4-pregnadiene-11 beta-dihydroxy-3,20-dione-21-trimethyl-acetic acid (Clocortolone Trimethyl-acetic acid) after e picutaneous application]. | 1978 |
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Clocortolone pivalate: a paired comparison clinical trial of a new topical steroid in eczema/atopic dermatitis. | 1980 Jan |
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Safety and efficacy of clocortolone pivalate 0.1 percent cream in the treatment of atopic dermatitis, contact dermatitis, and seborrheic dermatitis. | 1981 Jun |
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Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis. | 2003 Aug |
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Clocortolone Pivalate. | 2006 |
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Adherence to clocortolone pivalate cream 0.1% in a pediatric population with atopic dermatitis. | 2008 May |
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Clinical utility of clocortolone pivalate for the treatment of corticosteroid-responsive skin disorders: a systematic review. | 2012 |
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A Comprehensive Review of Clocortolone Pivalate 0.1% Cream: Structural Development, Formulation Characteristics, and Studies Supporting Treatment of Corticosteroid-responsive Dermatoses. | 2012 Jul |
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Identification and characterization of three impurities in clocortolone pivalate. | 2012 Mar 25 |
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Clocortolone pivalate: a topical corticosteroid with a unique structure. | 2013 Feb |
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The role of a midpotency topical corticosteroid and the clinical relevance of formulation characteristics in the management of commonly encountered eczematous and inflammatory dermatoses in adults and children: focus on the pharmacologic properties of clocortolone pivalate 0.1% cream. | 2013 Feb |
Patents
Substance Class |
Chemical
Created
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admin
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Fri Dec 15 16:21:03 GMT 2023
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Fri Dec 15 16:21:03 GMT 2023
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Record UNII |
85061HTR8T
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