U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C13H18Cl2N2O2.ClH
Molecular Weight 341.661
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SARCOLYSIN HYDROCHLORIDE, D-

SMILES

Cl.N[C@H](CC1=CC=C(C=C1)N(CCCl)CCCl)C(O)=O

InChI

InChIKey=OUUYBRCCFUEMLH-UTONKHPSSA-N
InChI=1S/C13H18Cl2N2O2.ClH/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;/h1-4,12H,5-9,16H2,(H,18,19);1H/t12-;/m1./s1

HIDE SMILES / InChI
Molecular Formula C13H18Cl2N2O2
Molecular Weight 305.2
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

The D-isomer of melphalan, known as medphalan, is less active against certain animal tumors and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer.

Originator

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
[Anti-tumor activity of optic isomers of sarcolysin].
1958-09

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:57:31 GMT 2025
Edited
by admin
on Mon Mar 31 21:57:31 GMT 2025
Record UNII
844HA6419R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
D-PHENYLALANINE MUSTARD HYDROCHLORIDE
Preferred Name English
SARCOLYSIN HYDROCHLORIDE, D-
Common Name English
MEDPHALAN HYDROCHLORIDE
Common Name English
ALANINE, 3-(P-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-, MONOHYDROCHLORIDE, D-
Systematic Name English
D-PHENYLALANINE, 4-(BIS(2-CHLOROETHYL)AMINO)-, MONOHYDROCHLORIDE
Systematic Name English
D-SARCOLYSINE HYDROCHLORIDE
Common Name English
Code System Code Type Description
FDA UNII
844HA6419R
Created by admin on Mon Mar 31 21:57:31 GMT 2025 , Edited by admin on Mon Mar 31 21:57:31 GMT 2025
PRIMARY
PUBCHEM
20188
Created by admin on Mon Mar 31 21:57:31 GMT 2025 , Edited by admin on Mon Mar 31 21:57:31 GMT 2025
PRIMARY
CAS
4213-32-5
Created by admin on Mon Mar 31 21:57:31 GMT 2025 , Edited by admin on Mon Mar 31 21:57:31 GMT 2025
PRIMARY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966