Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H20O4 |
| Molecular Weight | 348.3918 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C2OC[C@H]([C@@H](C3=CC=C(O)C=C3)C2=CC=C1O)C4=CC=C(O)C=C4
InChI
InChIKey=QVCAATSEPLQVBX-FPOVZHCZSA-N
InChI=1S/C22H20O4/c1-13-20(25)11-10-18-21(15-4-8-17(24)9-5-15)19(12-26-22(13)18)14-2-6-16(23)7-3-14/h2-11,19,21,23-25H,12H2,1H3/t19-,21-/m0/s1
| Molecular Formula | C22H20O4 |
| Molecular Weight | 348.3918 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
ME-344 is an isoflavone-derived antineoplastic agent. ME-344 is an active metabolite of NV-128. ME-344 exerts antitumor activity through inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I) and inducing caspase-independent cell death through the Akt/mammalian target of rapamycin pathway. ME-344 inhibited tubulin polymerization by interacting with tubulin near the colchicine-binding site. Furthermore, inhibition of tubulin polymerization was functionally important for ME-344 induced death. ME-344 is being developed for the treatment of solid tumors.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia. | 2016-08-02 |
|
| Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344. | 2016-08 |
|
| Phase 1, open-label, dose escalation, safety, and pharmacokinetics study of ME-344 as a single agent in patients with refractory solid tumors. | 2015-04-01 |
|
| Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). | 2015 |
|
| NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway. | 2009-07-15 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:06:59 GMT 2025
by
admin
on
Mon Mar 31 22:06:59 GMT 2025
|
| Record UNII |
843G0TDV51
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C101132
Created by
admin on Mon Mar 31 22:06:59 GMT 2025 , Edited by admin on Mon Mar 31 22:06:59 GMT 2025
|
PRIMARY | |||
|
68026984
Created by
admin on Mon Mar 31 22:06:59 GMT 2025 , Edited by admin on Mon Mar 31 22:06:59 GMT 2025
|
PRIMARY | |||
|
DB13062
Created by
admin on Mon Mar 31 22:06:59 GMT 2025 , Edited by admin on Mon Mar 31 22:06:59 GMT 2025
|
PRIMARY | |||
|
843G0TDV51
Created by
admin on Mon Mar 31 22:06:59 GMT 2025 , Edited by admin on Mon Mar 31 22:06:59 GMT 2025
|
PRIMARY | |||
|
DTXSID701031261
Created by
admin on Mon Mar 31 22:06:59 GMT 2025 , Edited by admin on Mon Mar 31 22:06:59 GMT 2025
|
PRIMARY | |||
|
CHEMBL3545320
Created by
admin on Mon Mar 31 22:06:59 GMT 2025 , Edited by admin on Mon Mar 31 22:06:59 GMT 2025
|
PRIMARY | |||
|
1374524-68-1
Created by
admin on Mon Mar 31 22:06:59 GMT 2025 , Edited by admin on Mon Mar 31 22:06:59 GMT 2025
|
PRIMARY | |||
|
300000041410
Created by
admin on Mon Mar 31 22:06:59 GMT 2025 , Edited by admin on Mon Mar 31 22:06:59 GMT 2025
|
PRIMARY |