U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C46H64O2
Molecular Weight 648.9992
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 6
Charge 0

SHOW SMILES / InChI
Structure of MENAQUINONE 7

SMILES

CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O

InChI

InChIKey=RAKQPZMEYJZGPI-LJWNYQGCSA-N
InChI=1S/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,38-26+,39-28+,40-32+

HIDE SMILES / InChI
Molecular Formula C46H64O2
Molecular Weight 648.9992
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 6
Optical Activity NONE

Description

Vitamin K is a fat-soluble vitamin, which exists in two different forms in nature: vitamin K1 (phylloquinone or phytonadione) and vitamin K2 (menaquinones), a feature of which is a long polyprenyl lateral chain. Menaquinone-7 (MK-7) is a form of vitamin K2 that occurs naturally in some animal-derived and is available as an ingredient of dietary supplements. A novel method of marking five different cis/trans isomers of vitamin K2 (MK-7) (including 6-CIS form) in dietary supplements recently was developed and validated.

Approval Year

2018
436
PubMed

PubMed

TitleDatePubMed
US Pharmacopeial Convention safety evaluation of menaquinone-7, a form of vitamin K.
2017 Jul 1
Identification of cis/trans isomers of menaquinone-7 in food as exemplified by dietary supplements.
2018 Mar 15
Analysis of Menaquinone-7 Content and Impurities in Oil and Non-Oil Dietary Supplements.
2018 May 1
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:44:27 UTC 2023
Edited
by admin
on Fri Dec 15 19:44:27 UTC 2023
Record UNII
8427BML8NY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MENAQUINONE 7
HSDB   MI  
Common Name English
1,4-NAPHTHALENEDIONE, 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-HEPTAMETHYL-2,6,10,14,18,22,26-OCTACOSAHEPTAENYL)-3-METHYL-
Common Name English
Menaquinone-7 [WHO-DD]
Common Name English
MENAQUINONE-7 [DSC]
Common Name English
1,4-NAPHTHOQUINONE, 2-(3,7,11,15,19,23,27-HEPTAMETHYL-2,6,10,14,18,22,26-OCTACOSAHEPTAENYL)-3-METHYL-, (ALL-E)-
Common Name English
MENAKINON 7
Common Name English
MK7
Common Name English
MENAQUINONE 7 [MI]
Common Name English
1,4-NAPHTHALENEDIONE, 2-(3,7,11,15,19,23,27-HEPTAMETHYL-2,6,10,14,18,22,26-OCTACOSAHEPTAENYL)-3-METHYL-, (ALL-E)-
Common Name English
MENAQUINONE-7 [USP-RS]
Common Name English
MENAQUINONE K7
Common Name English
VITAMIN MK 7
Common Name English
MENAQUINONE-7 [INCI]
Common Name English
MENAQUINONE-7
DSC   USP-RS   WHO-DD  
INCI  
Official Name English
MENAQUINONE 7 [HSDB]
Common Name English
VITAMIN K2(35)
Common Name English
Code System Code Type Description
FDA UNII
8427BML8NY
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
MESH
C062629
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
245
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
HSDB
1040
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
PUBCHEM
5287554
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
EPA CompTox
DTXSID801317474
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
RXCUI
2001758
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
EVMPD
SUB124929
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
DAILYMED
8427BML8NY
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
CHEBI
44245
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
DRUG BANK
DB13075
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
887
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
SMS_ID
100000146040
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
MERCK INDEX
m7171
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY Merck Index
RS_ITEM_NUM
1381119
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
CAS
2124-57-4
Created by admin on Fri Dec 15 19:44:27 UTC 2023 , Edited by admin on Fri Dec 15 19:44:27 UTC 2023
PRIMARY
Related Record Type Details
Structure of MENAQUINONE-7, (2Z)-
IMPURITY -> PARENT
USP
Structure of MENAQUINONE 6
IMPURITY -> PARENT
USP
Structure of MENAQUINONE-7, (6Z)-
IMPURITY -> PARENT
USP
Structure of MENAQUINONE-7, (14Z)-
IMPURITY -> PARENT
USP
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966