Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C25H37NO2 |
| Molecular Weight | 383.5668 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CC[C@@]2(C)C3=CC(O)=CC=C3C[C@@H]1[C@@]2(C)CCC(=O)CCC4CCCC4
InChI
InChIKey=LOYWOYCPSWPKFH-DSNGMDLFSA-N
InChI=1S/C25H37NO2/c1-24-14-15-26(3)23(16-19-9-11-21(28)17-22(19)24)25(24,2)13-12-20(27)10-8-18-6-4-5-7-18/h9,11,17-18,23,28H,4-8,10,12-16H2,1-3H3/t23-,24+,25-/m1/s1
| Molecular Formula | C25H37NO2 |
| Molecular Weight | 383.5668 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Quadazocine is a substituted hexahydro-2,6-methano-3-benzazocine patented by Sterling Drug Inc. as analgesics and narcotic antagonist. Quadazocine is a potent antagonist of μ opioid receptor, less potent antagonist of κ and δ opioid receptors. In monkeys for whom responding was reinforced by food delivery, quadazocine blocks the rate-decreasing effects of the µ-agonists alfentanil and fentanyl with greater potency than it blocked the rate-decreasing effects of the κ-agonists U69,593
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Sex differences in opioid antinociception in rhesus monkeys: antagonism of fentanyl and U50,488 by quadazocine. | 2002-06 |
|
| Effects of flupenthixol and quadazocine on self-administration of speedball combinations of cocaine and heroin by rhesus monkeys. | 1999-10 |
|
| Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. | 1998-03 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:23:52 GMT 2025
by
admin
on
Mon Mar 31 21:23:52 GMT 2025
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| Record UNII |
840PPY007V
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| Record Status |
Validated (UNII)
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| Record Version |
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840PPY007V
Created by
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71076-28-3
Created by
admin on Mon Mar 31 21:23:52 GMT 2025 , Edited by admin on Mon Mar 31 21:23:52 GMT 2025
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PRIMARY |