Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H4ClN5 |
| Molecular Weight | 169.572 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(Cl)=C2NC=NC2=N1
InChI
InChIKey=RYYIULNRIVUMTQ-UHFFFAOYSA-N
InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
| Molecular Formula | C5H4ClN5 |
| Molecular Weight | 169.572 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity. | 2009-06-01 |
|
| (Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity. | 2009-05-28 |
|
| Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides. | 2009-03-20 |
|
| 2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling. | 2008-03-07 |
|
| Synthesis of altritol nucleoside phosphoramidites for oligonucleotide synthesis. | 2007-09 |
|
| Synthesis of 2,2,3-tris(hydroxymethyl)methylenecyclopropane analogues of nucleosides. | 2007 |
|
| Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines. | 2007 |
|
| Synthesis of "reversed" methylenecyclopropane analogues of antiviral phosphonates. | 2007 |
|
| Efficient N-arylation and N-alkenylation of the five DNA/RNA nucleobases. | 2006-11-24 |
|
| 9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1. | 2006-10-05 |
|
| Oxanosine is a substrate of adenosine deaminase. Implications for the quest for a toxicological marker for nitrosation activity. | 2005-12 |
|
| Synthesis and preliminary biological evaluation of O6-[4-(2-[18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in cancer chemotherapy. | 2005-10-15 |
|
| Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages. | 2005-04-15 |
|
| Stereoselective synthesis of 9-beta-d-arabianofuranosyl guanine and 2-amino-9-(beta-d-arabianofuranosyl)purine. | 2005-02-01 |
|
| Synthesis of 2-amino-6-(4-[11C]methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester as a novel potential PET gene reporter probe for HBV and HSV-tk in cancers. | 2005-01-17 |
|
| Conformationally constrained purine mimics. Incorporation of adenine and guanine into spirocyclic nucleosides. | 2004-08-20 |
|
| Syntheses and base-pairing properties of locked nucleic acid nucleotides containing hypoxanthine, 2,6-diaminopurine, and 2-aminopurine nucleobases. | 2004-05-28 |
|
| Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides. | 2004-01-29 |
|
| Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids. | 2003-12 |
|
| Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol. | 2003-11-21 |
|
| Synthesis and preliminary biological evaluation of radiolabeled O6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in breast cancer. | 2003-05 |
|
| Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane analogues of nucleosides. Variation of purine-6 substituents and activity against herpesviruses and hepatitis B virus. | 2003-04-10 |
|
| Synthesis of 7-hydroxy(phenyl)ethylguanines by alkylation of 2-amino-6-chloropurine with allyl-protected bromohydrins. | 2003-03-06 |
|
| Synthesis of (Z)-(2,3-bis-hydroxymethyl)methylenecyclopropane analogues of purine nucleosides. | 2003-03 |
|
| Efficient syntheses of 2-chloro-2'-deoxyadenosine (cladribine) from 2'-deoxyguanosine(1). | 2003-02-07 |
|
| Three 2-aminopurine derivatives. | 2003-01 |
|
| Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents. | 2002-03-14 |
|
| Synthesis of 2-alkyl-substituted-N6-methyladenine derivatives as potential adenosine receptor ligand. | 2001-12 |
|
| Methylene-gem-difluorocyclopropane analogues of nucleosides: synthesis, cyclopropene-methylenecyclopropane rearrangement, and biological activity. | 2001-11-08 |
|
| Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | 1995-11-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:19:46 GMT 2025
by
admin
on
Mon Mar 31 19:19:46 GMT 2025
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| Record UNII |
83V03P835E
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| Record Status |
Validated (UNII)
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| Record Version |
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