ONCR-177

Investigational

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 15:19:20 GMT 2023` Edited by `admin` on `Sat Dec 16 15:19:20 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	VIRUS
Source Materials State	LIVE ATTENUATED GENETICALLY MODIFIED
Organism Family	Herpesviridae
Organism Genus	Simplexvirus
Organism Species	human herpesvirus 1
Author	NONE
Infraspecific Type	RECOMBINANT VECTOR
Infraspecific Name	ONCR-177
Part	WHOLE
Record UNII	83P3OQ67ZT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ONCR-177

Common Name

English

HSV-1 MIR-ATTENUATED ONCOLYTIC ONCR-177

Common Name

English

ONCR-177, AN MIR-ATTENUATED ONCOLYTIC HSV-1 EXPRESSING ARMED WITH FIVE TRANSGENES (THE NK AND T CELL ACTIVATING CYTOKINE IL-12, THE CHEMOKINES CCL4 AND FLT3LG (EXTRACELLULAR DOMAIN) TO ALLOW FOR EXPANSION AND RECRUITMENT OF CLASSICAL DENDRITIC CELLS, AND

Common Name

English

Code System Code Type Description

FDA UNII

83P3OQ67ZT

Created by admin on Sat Dec 16 15:19:20 GMT 2023 , Edited by admin on Sat Dec 16 15:19:20 GMT 2023

PRIMARY

NCI_THESAURUS

C171540

Created by admin on Sat Dec 16 15:19:20 GMT 2023 , Edited by admin on Sat Dec 16 15:19:20 GMT 2023

PRIMARY

Structural Modifications

Modification Type	Location Type	Fragment Name	Fragment Approval
GENE FRAGMENT REPLACEMENT		UNSPECIFIED SUBSTANCE	d839e181 (not in database)
GENE FRAGMENT REPLACEMENT		UNSPECIFIED SUBSTANCE	00bd00a7 (not in database)
GENE FRAGMENT REPLACEMENT	SITE_SPECIFIC	UNSPECIFIED SUBSTANCE	9ec0f061 (not in database)
GENE FRAGMENT REPLACEMENT	SITE_SPECIFIC	UNSPECIFIED SUBSTANCE	3d0b6210 (not in database)
VECTOR EXPRESSED PROTEIN		UNSPECIFIED SUBSTANCE	33d1b192 (not in database)
GENE FRAGMENT REPLACEMENT		UNSPECIFIED SUBSTANCE	3e356590 (not in database)