METHYLSAMIDORPHAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H29N2O4
Molecular Weight	385.4767
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12CC3=C(C(O)=C(C=C3)C(N)=O)[C@@]5(CC[N@+]1(C)CC4CC4)CC(=O)CC[C@@]25O

InChI

InChIKey=ATCVVCBJNHXIEX-ZAHKBLQYSA-O

InChI=1S/C22H28N2O4/c1-24(12-13-2-3-13)9-8-21-11-15(25)6-7-22(21,28)17(24)10-14-4-5-16(20(23)27)19(26)18(14)21/h4-5,13,17,28H,2-3,6-12H2,1H3,(H2-,23,26,27)/p+1/t17-,21-,22-,24-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H28N2O4
Molecular Weight	384.4687
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	3 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://doi.org/10.1016/S0016-5085(11)60552-0 | https://www.businesswire.com/news/home/20120530006471/en/Alkermes-Announces-Results-Phase-2-Study-ALKS

Methylsamidorphan (previously known as ALKS 37), an opioid receptor antagonist that was developed to treat opioid-induced bowel dysfunction. This drug participated in phase II clinical trial to evaluate the safety, tolerability, and efficacy when administered daily for 4 weeks to adults with Opioid-induced Constipation. However, the product profile did not satisfy the pre-specified criteria for advancing into phase III clinical trials. Based on this evaluation, was made the decision of discontinuation of the further methylsamidorphan study.

Approval Year

Sample Use Guides

In Vivo Use Guide

Capsules for oral administration

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:57:33 GMT 2023` Edited by `admin` on `Sat Dec 16 01:57:33 GMT 2023`
Record UNII	8347HC35J6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METHYLSAMIDORPHAN

Official Name

English

RDC-1036-00

Code

English

ALKS-37 CATION

Code

English

MORPHINANIUM, 3-(AMINOCARBONYL)-17-(CYCLOPROPYLMETHYL)-4,14-DIHYDROXY-17-METHYL-6-OXO-, (17R)-

Systematic Name

English

RDC-1036 CATION

Code

English

METHYLSAMIDORPHAN ION

Common Name

English

RDC-103600

Code

English

Methylsamidorphan [WHO-DD]

Common Name

English

ALKS37

Code

English

(17R)-3-Carbamoyl-17-(cyclopropylmethyl)-4,14-dihydroxy-17-methyl-6-oxomorphinanium

Systematic Name

English

RDC-103603

Code

English

METHYLSAMIDORPHAN [USAN]

Common Name

English

METHYLSAMIDORPHAN CATION

Common Name

English

Code System Code Type Description

PUBCHEM

71484494