Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H8N2.2ClH |
| Molecular Weight | 133.02 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CNNC
InChI
InChIKey=WLDRFJDGKMTPPV-UHFFFAOYSA-N
InChI=1S/C2H8N2.2ClH/c1-3-4-2;;/h3-4H,1-2H3;2*1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C2H8N2 |
| Molecular Weight | 60.0983 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats. | 2003-12 |
|
| Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. | 2003-10 |
|
| Mechanism of formation of hydrogen trioxide (HOOOH) in the ozonation of 1,2-diphenylhydrazine and 1,2-dimethylhydrazine: an experimental and theoretical investigation. | 2003-09-24 |
|
| n-3 polyunsaturated fatty acids decrease mucosal/epidermal reactions and enhance antitumour effect of ionising radiation with inhibition of tumour angiogenesis. | 2003-09-15 |
|
| Dietary supplementation of conjugated linoleic acid reduces colon tumor incidence in DMH-treated rats by increasing apoptosis with modulation of biomarkers. | 2003-09 |
|
| Rapid induction of colorectal tumors in rats initiated with 1,2-dimethylhydrazine followed by dextran sodium sulfate treatment. | 2003-08-20 |
|
| Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin. | 2003-08-20 |
|
| Validation of a flow cytometric acridine orange micronuclei methodology in rats. | 2003-07-25 |
|
| Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats. | 2003-07-10 |
|
| High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine. | 2003-06 |
|
| Effect of vanadium on colonic aberrant crypt foci induced in rats by 1,2 dimethyl hydrazine. | 2003-05 |
|
| Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. | 2003-04 |
|
| Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. | 2003-03-12 |
|
| Modulation of carcinogenic response and antioxidant enzymes of rats administered with 1,2-dimethylhydrazine by Picroliv. | 2003-03-10 |
|
| Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine. | 2003-03 |
|
| Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo. | 2003-03 |
|
| Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model. | 2003-02-28 |
|
| Abnormalities of the cadherin-catenin complex in chemically-induced colo-rectal carcinogenesis. | 2003-02 |
|
| Anticarcinogenic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione a curcumin analog on DMH-induced colon cancer model. | 2003-02 |
|
| Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line. | 2003-01-14 |
|
| Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas. | 2003-01-13 |
|
| Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. | 2003 |
|
| Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses. | 2002-12-15 |
|
| Distinction of carcinogens from mutagens by induction of liver cell foci in a model for detection of initiation activity. | 2002-12-15 |
|
| Effects of high molybdenum intake on 1,2-dimethylhydrazine-induced intestinal tumors in rats. | 2002-12 |
|
| Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model. | 2002-12 |
|
| DNA alkylation and repair in the large bowel: animal and human studies. | 2002-11 |
|
| Variability of cell proliferation in the proximal and distal colon of normal rats and rats with dimethylhydrazine induced carcinogenesis. | 2002-10 |
|
| Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas. | 2002-09-30 |
|
| Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. | 2002-09-08 |
|
| A stable and sensitive genotoxic testing system based on DNA damage induced gene expression in Saccharomyces cerevisiae. | 2002-08-26 |
|
| Conjugated linoleic acid (CLA) inhibits growth of Caco-2 colon cancer cells: possible mediation by oleamide. | 2002-08-15 |
|
| Increased incidence rate of colorectal tumors due to the intake of a soluble dietary fiber in rat chemical carcinogenesis can be suppressed by substituting partially an insoluble dietary fiber for the soluble one. | 2002-08-01 |
|
| Enhancement of circulatory antioxidants by fenugreek during 1,2-dimethylhydrazine-induced rat colon carcinogenesis. | 2002-08 |
|
| Role of yoghurt in the prevention of colon cancer. | 2002-08 |
|
| Bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione (a curcumin analog) ameliorates DMH-induced hepatic oxidative stress during colon carcinogenesis. | 2002-07 |
|
| Collaborative validation study of the in vivo micronucleus test using mouse colonic epithelial cells. | 2002-06-27 |
|
| p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas. | 2002-06-01 |
|
| Inhibitory effect of small amounts of cellulose on colonic carcinogenesis with low-dose carcinogen. | 2002-06 |
|
| Influence of dietary components associated with high or low risk of colon cancer on apoptosis in the rat colon. | 2002-06 |
|
| Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2). | 2002-05-20 |
|
| Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. | 2002-05 |
|
| Chemistry of stable iminopropadienones, RN=C=C=C=O. | 2002-04-19 |
|
| Experimental model for the study of perianastomotic recurrence in colorectal cancer. | 2002-03 |
|
| Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. | 2002-02 |
|
| Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats. | 2002 |
|
| Inhibition of tumor progression and neoangiogenesis using cyclic RGD-peptides in a chemically induced colon carcinoma in rats. | 2002 |
|
| [Circadian features of carcinogenesis of the large intestine induced by 1,2-dimethylhydrazine in rats]. | 2002 |
|
| Different effects of short- and long-chained fructans on large intestinal physiology and carcinogen-induced aberrant crypt foci in rats. | 2002 |
|
| Protective action of propolis on the rat colon carcinogenesis. | 2002 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:03:08 GMT 2025
by
admin
on
Mon Mar 31 19:03:08 GMT 2025
|
| Record UNII |
8326154U0N
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C45176
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admin on Mon Mar 31 19:03:08 GMT 2025 , Edited by admin on Mon Mar 31 19:03:08 GMT 2025
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| Code System | Code | Type | Description | ||
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306-37-6
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73759
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8326154U0N
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DTXSID6020517
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9380
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206-183-5
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60518
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C29788
Created by
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
