Y-320

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H29ClN6O2
Molecular Weight	505.011
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C=NN1C2=CC=C(Cl)C=C2)C(=O)NC3=CC(C#N)=C(C=C3)N4CCC(CC4)N5CCOCC5

InChI

InChIKey=BWZNJVZTAWBIFG-UHFFFAOYSA-N

InChI=1S/C27H29ClN6O2/c1-19-25(18-30-34(19)24-5-2-21(28)3-6-24)27(35)31-22-4-7-26(20(16-22)17-29)33-10-8-23(9-11-33)32-12-14-36-15-13-32/h2-7,16,18,23H,8-15H2,1H3,(H,31,35)

HIDE SMILES / InChI

Molecular Formula	C27H29ClN6O2
Molecular Weight	505.011
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17984577

Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. Y-320 is an orally active a new phenylpyrazoleanilide immunomodulator which inhibits IL-17 production by CD4 T cells stimulated with IL-15, providing a useful therapy for RA.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Interleukin-15 1 Target ID: P40933 Gene ID: 3600.0 Gene Symbol: IL15 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/24366113	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatoid arthritis 316 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24366113	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[A new orally active anti-rheumatic drug targets IL-15 and IL-17].	2007 Oct	17984577

Patents

Sample Use Guides

In Vivo Use Guide

in mice: 0.3 to 3 mg/kg orally

Route of Administration: Oral

In Vitro Use Guide

In human peripheral blood CD4 T cells, a significant level of IL-17 was produced by stimulation with rh-IL-15 (3 to 100 ng/mL). Y-320 (10 to 300 nM) significantly inhibited IL-17 production by human CD4 T cells stimulated with rh-IL-15 (100 ng/mL) with an IC50 value of 57.4 nM. These results clearly indicate that Y-320 inhibits IL-17 production from human CD4 T cells including Th17 cells and memory type CD4 T cells stimulated with IL-15.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:13:25 GMT 2023` Edited by `admin` on `Sat Dec 16 17:13:25 GMT 2023`
Record UNII	82S7NR4B46
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Y-320

Code

English

1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-MORPHOLIN-4-YLPIPERIDIN-1-YL)PHENYL)-5-METHYLPYRAZOLE-4-CARBOXAMIDE

Systematic Name

English

1H-PYRAZOLE-4-CARBOXAMIDE, 1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-(4-MORPHOLINYL)-1-PIPERIDINYL)PHENYL)-5-METHYL-

Systematic Name

English

1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-(4-MORPHOLINYL)-1-PIPERIDINYL)PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

82S7NR4B46