HARMAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H10N2
Molecular Weight	182.2212
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC=CC2=C1NC3=C2C=CC=C3

InChI

InChIKey=PSFDQSOCUJVVGF-UHFFFAOYSA-N

InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3

HIDE SMILES / InChI

Molecular Formula	C12H10N2
Molecular Weight	182.2212
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Benzodiazepine receptors; peripheral & central 9 Target ID: CHEMBL2096683 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6255348	Binding Agent 1064
Monoamine oxidase A 49 Target ID: CHEMBL1951 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16139309	Inhibitor 8297

PubMed

Title	Date	PubMed
Garbage catastrophe theory of aging: imperfect removal of oxidative damage?	2001	11333111
Identification of co-mutagenic chlorinated harmans in final effluent from a sewage treatment plant.	2001 Apr 5	11287299
Genotoxic effects of the alkaloids harman and harmine assessed by comet assay and chromosome aberration test in mammalian cells in vitro.	2001 Dec	11903953
Degradation of tetrahydro-beta-carbolines in the presence of nitrite: HPLC-MS analysis of the reaction products.	2001 Dec	11743798
Neural substrates of mathematical reasoning: a functional magnetic resonance imaging study of neocortical activation during performance of the necessary arithmetic operations test.	2001 Jan	11216882
Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali.	2002 Feb	11936507
Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease.	2002 Jun	11900856
Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline.	2002 Mar 25	11909766
Affinitive separation and on-line identification of antitumor components from Peganum nigellastrum by coupling a chromatographic column of target analogue imprinted polymer with mass spectrometry.	2002 May 15	12038761
Natural variations of precursors in pig meat affect the yield of heterocyclic amines--effects of RN genotype, feeding regime, and sex.	2002 May 8	11982426
Atypical [(3)H]clonidine binding sites in human caudate and platelets on cryostat-cut sections.	2003 Dec	15028603
Harmane induces anxiolysis and antidepressant-like effects in rats.	2003 Dec	15028588
Endogenous beta-carbolines as clonidine-displacing substances.	2003 Dec	15028582
Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.	2003 Dec 15	14660022
Influence of antioxidants in virgin olive oil on the formation of heterocyclic amines in fried beefburgers.	2003 Nov	12963012
He's the dean of CEOs. Harman has held the top job at his West Virginia hospital for nearly 40 years--and counting.	2004 Aug 2	15332525
Dermatology in Nigeria: evolution, establishment and current status.	2004 Mar	15009399
Blood harmane concentrations and dietary protein consumption in essential tremor.	2005 Aug 9	16087903
Chronological and physiological ageing in a polar and a temperate mud clam.	2005 May	15811429
Harmane inhibits serotonergic dorsal raphe neurons in the rat.	2005 Nov	16133137
Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.	2005 Oct 25	15878313
Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae).	2006 Jun 30	16443341

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:43:12 GMT 2023` Edited by `admin` on `Fri Dec 15 19:43:12 GMT 2023`
Record UNII	82D6J0535P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HARMAN

Systematic Name

English

NSC-54439

Code

English

HARMAN [MI]

Common Name

English

9H-PYRIDO(3,4-B)INDOLE, 1-METHYL-

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

207-642-2