KOS-1584

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H39NO5S
Molecular Weight	489.667
Optical Activity	( - )
Defined Stereocenters	5 / 5
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1\C=C\CC(C)=CC[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\C2=CSC(C)=N2

InChI

InChIKey=XAYAKDZVINDZGB-BMVMHAJPSA-N

InChI=1S/C27H39NO5S/c1-16-9-8-10-17(2)25(31)19(4)26(32)27(6,7)23(29)14-24(30)33-22(12-11-16)18(3)13-21-15-34-20(5)28-21/h8,10-11,13,15,17,19,22-23,25,29,31H,9,12,14H2,1-7H3/b10-8+,16-11-,18-13+/t17-,19+,22-,23-,25-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H39NO5S
Molecular Weight	489.667
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21874318 | https://www.ncbi.nlm.nih.gov/pubmed/17656562

KOS-1584 is a second-generation epothilone D analog designed to have less toxicity, more potency, and higher solubility compared with epothilone D. It has a broad spectrum of potent antiproliferative activity on tumor cells. Currently, KOS-1584 is under clinical evaluation.

Originator

Approval Year

PubMed

Title	Date	PubMed
Epothilones in epithelial ovarian, fallopian tube, or primary peritoneal cancer: a systematic review.	2015	26316786
Phase I dose escalation study of KOS-1584, a novel epothilone, in patients with advanced solid tumors.	2012-02	21874318
Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues.	2007-07	17656562

Patents

Sample Use Guides

In Vivo Use Guide

The recommended phase II dose is 36 mg/m2.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:02:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:02:18 GMT 2025`
Record UNII	82481G197K
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

R-1645

Preferred Name

English

KOS-1584

Code

English

OXACYCLOHEXADECA-10,13-DIENE-2,6-DIONE, 4,8-DIHYDROXY-5,5,7,9,13-PENTAMETHYL-16-((1E)-1-METHYL-2-(2-METHYL-4-THIAZOLYL)ETHENYL)-, (4S,7R,8S,9S,10E,13Z,16S)-

Systematic Name

English

9,10-TRANS-DEHYDROEPOTHILONE D

Common Name

English

R1645

Code

English

(E)-9,10-DEHYDROEPOTHILONE D

Common Name

English

(4S,7R,8S,9S,10E,13Z,16S)-4,8-DIHYDROXY-5,5,7,9,13-PENTAMETHYL-16-((E)-1-METHYL-2-(2-METHYL-1,3-THIAZOL-4-YL)VINYL)OXACYCLOHEXADECA-10,13-DIENE-2,6-DIONE

Systematic Name

English

(E)-9,10-DIDEHYDROEPOTHILONE D

Common Name

English

DEHYDELONE

Common Name

English

Code System Code Type Description

SMS_ID

300000041376