PIVALIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H10O2
Molecular Weight	102.1317
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)C(O)=O

InChI

InChIKey=IUGYQRQAERSCNH-UHFFFAOYSA-N

InChI=1S/C5H10O2/c1-5(2,3)4(6)7/h1-3H3,(H,6,7)

HIDE SMILES / InChI

Molecular Formula	C5H10O2
Molecular Weight	102.1317
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.	2005 Dec	16601779
Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism.	2006	16752941
Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid.	2006 Aug	16826461
Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols.	2006 Aug	16713699
Palladium-catalyzed benzene arylation: incorporation of catalytic pivalic acid as a proton shuttle and a key element in catalyst design.	2006 Dec 27	17177387
Synthesis, structure, and magnetic properties of (6-9)-nuclear Ni(II) trimethylacetates and their heterospin complexes with nitroxides.	2006 Jul 10	16813397
Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst.	2006 Jul 21	16839166
Synthesis, reactivities, and magnetostructural properties of FeIII, FeIII-O-FeIII, and ZnIIFeIII-O-FeIIIZnII complexes of a tetraiminodiphenolate macrocycle.	2006 Jun 12	16749848
Photocatalytic oxygenation of pivalic acid with molecular oxygen via photoinduced electron transfer using 10-methylacridinium ions.	2006 Mar 23	16539406
New mixed-valence MnII2MnIII2 clusters exhibiting an unprecedented MnII/III oxidation state distribution in their magnetically coupled cores.	2006 Mar 28	16538272
Studies of a molecular hourglass: synthesis and magnetic characterisation of a cyclic dodecanuclear {Cr10Cu2} complex.	2006 Nov 6	17009364
Pyrones to pyrans: enantioselective radical additions to acyloxy pyrones.	2006 Oct 18	17031933
Induction of parturition in dairy cattle and its effects on health and subsequent lactation and reproductive performance.	2006 Sep	16958626
1D helical polymeric chain with a pseudo-5(3) screw axis formed by cuprophilicity. synthesis and crystal structure of copper(I) pivalate.	2006 Sep 18	16961347
[Luliberin analogues exhibiting a cytotoxic effect on tumor cells in vitro].	2006 Sep-Oct	17042263
Chromium-catalyzed arylmagnesiation of alkynes.	2007 Apr 12	17352489
Inhibitory purinergic transmission in mouse caecum: role for P2Y1 receptors as prejunctional modulators of ATP release.	2007 Dec 12	17997228
Tixocortol pivalate: what is the right concentration?	2007 Jul	17577357
Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status.	2007 Jul	17482425
Conformational enantiomeric disorder in tripivaloylmethane.	2007 Jun	17551202
Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon.	2007 May	17351663
Toward a magnetostructural correlation for a family of Mn6 SMMs.	2007 Oct 17	17887755
Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid.	2007 Sep	17724113
Cross-coupling of aryl/alkenyl pivalates with organozinc reagents through nickel-catalyzed C-O bond activation under mild reaction conditions.	2008	19016280
Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment.	2008	18762717
Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias.	2008	18537607
Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors.	2008 Apr	18194419
Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation.	2008 Apr 1	18308574
Effectiveness of UV-based advanced oxidation processes for the remediation of hydrocarbon pollution in the groundwater: a laboratory investigation.	2008 Apr 15	17890002
Scanning tunneling microscopy study of black dye and deoxycholic acid adsorbed on a rutile TiO2(110).	2008 Aug 5	18590297
Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation.	2008 Dec 11	19007111
Ion-pair interaction in pyridinium carboxylate solutions.	2008 Feb 7	18189374
Protic ionic liquids: physicochemical properties and behavior as amphiphile self-assembly solvents.	2008 Jan 24	18166036
Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope.	2008 Jul 4	18543991
Au-catalyzed synthesis of (1Z,3E)-2-pivaloxy-1,3-dienes from propargylic pivalates.	2008 Mar 26	18311985
Cross-coupling reactions of aryl pivalates with boronic acids.	2008 Nov 5	18839946
An expedient route to Montanine-type Amaryllidaceae alkaloids: total syntheses of (-)-brunsvigine and (-)-manthine.	2008 Oct 3	18781802
Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.	2008 Sep	18680316
Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism.	2009	19571472
C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses.	2009	19280618
Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst.	2009	19115287
Family of heterometallic semicircular Mn(III)2Ln(III)3 strands.	2009 Apr 20	19317423
Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2.	2009 Aug 14	19539806
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues.	2009 Dec	19447154
Tridecanuclear [Mn(III)5Ln(III)8] complexes derived from N-(t)butyl-diethanolamine: synthesis, structures, and magnetic properties.	2009 Jul 20	19530694
Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells.	2009 Jun	19371256
Development of selective agonists and antagonists of P2Y receptors.	2009 Mar	18600475
Tetra-, tri-, and mononuclear manganese(II/III) complexes of a phenol-based N2O2 capping ligand: use of carboxylates as ancillary ligands in tuning the nuclearity of the complexes.	2009 Mar 2	19235946
C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition.	2009 Mar 4	19206533
Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds.	2009 Mar 6	19206211

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:53:39 GMT 2023` Edited by `admin` on `Sat Dec 16 04:53:39 GMT 2023`
Record UNII	813RE8BX41
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PIVALIC ACID

Systematic Name

English

2,2-DIMETHYLPROPANOIC ACID [HSDB]

Common Name

English

NEOPENTANOIC ACID

Systematic Name

English

2,2-DIMETHYLPROPANOIC ACID

Systematic Name

English

NSC-65449

Code

English

PIVALIC ACID [MI]

Common Name

English

TRIMETHYLACETIC ACID

Systematic Name

English

Code System Code Type Description

FDA UNII

813RE8BX41