CANTUZUMAB MERTANSINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 20:36:53 GMT 2025` Edited by `admin` on `Mon Mar 31 20:36:53 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	7Z7EUX7R6M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAYTANSINE, N2-DEACETYL-N2-(3-MERCAPTO-1-OXOPROPYL)-, CONJUGATED HUMANIZED C242 MONOCLONAL ANTIBODY

Preferred Name

English

CANTUZUMAB MERTANSINE

Official Name

English

IMMUNOGLOBULIN G1, ANTI-(MUCIN CANAG) HUMAN-MOUSE MONOCLONAL C242 HEAVY CHAIN), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL C242 LIGHT CHAIN, DIMER, COMPOUND WITH N(SUP 2')-DEACETYL-N(SUP 2')-(3-SULFANYLPROPANOYL)MAYTANSINE

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(MUCIN CANAG) (HUMAN-MOUSE MONOCLONAL C242 HEAVY CHAIN), DISULPHIDE WITH HUMAN-MOUSE MONOCLONAL C242 LIGHT CHAIN, DIMER, COMPOUND WITH N(SUP 2')-DEACETYL-N(SUP 2')-(3-MERCAPTO-1-OXOPROPYL)MAYTANSINE (1:4)

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(MUCIN CANAG) HUMAN-MOUSE MONOCLONAL C242 HEAVY CHAIN), DISULPHIDE WITH HUMAN-MOUSE MONOCLONAL C242 LIGHT CHAIN, DIMER, COMPOUND WITH N(SUP 2')-DEACETYL-N(SUP 2')-(3-SULPHANYLPROPANOYL)MAYTANSINE

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(MUCIN CANAG) (HUMAN-MOUSE MONOCLONAL C242 HEAVY CHAIN), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL C242 LIGHT CHAIN, DIMER, COMPOUND WITH N(SUP 2')-DEACETYL-N(SUP 2')-(3-MERCAPTO-1-OXOPROPYL)MAYTANSINE (1:4)

Common Name

English

HUC-242-DM1

Code

English

Cantuzumab mertansine [WHO-DD]

Common Name

English

cantuzumab mertansine [INN]

Common Name

English

SB-408075

Code

English

CANTUZUMAB MERTANSINE [USAN]

Common Name

English

HUC242-DM1

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C20401

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

FDA ORPHAN DRUG

138400

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

Code System Code Type Description

SMS_ID

300000025311

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

ChEMBL

CHEMBL1742997

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

FDA UNII

7Z7EUX7R6M

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

INN

8223

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

MESH

C483240

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

NCI_THESAURUS

C95782

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

USAN

NN-18

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

CAS

400010-39-1

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

WIKIPEDIA

Cantuzumab mertansine

Created by admin on Mon Mar 31 20:36:53 GMT 2025 , Edited by admin on Mon Mar 31 20:36:53 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
3_23	3_93
4_23	4_93
3_139	3_199
4_139	4_199
1_146	1_202
2_146	2_202
1_222	3_219
2_222	4_219
1_228	2_228
1_231	2_231
1_263	1_323
2_263	2_323
1_369	1_427
2_369	2_427

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					I903D7RK7W

MUCIN-1

TARGET->LIGAND

Related Record Type Details


					7Z7EUX7R6M

CANTUZUMAB MERTANSINE

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]			Amount:	PIDOLIC ACID	SZB83O1W42
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	K	Amount:	MERTANSINE N6-LYSYL-4-SULFANYLPENTANAMIDE DISULFIDE	3QN0K2A6Q8

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL