Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H4Cl6 |
| Molecular Weight | 360.878 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC(Cl)=C(C=C1Cl)C2=C(Cl)C(Cl)=C(Cl)C=C2
InChI
InChIKey=RPUMZMSNLZHIGZ-UHFFFAOYSA-N
InChI=1S/C12H4Cl6/c13-7-2-1-5(11(17)12(7)18)6-3-9(15)10(16)4-8(6)14/h1-4H
| Molecular Formula | C12H4Cl6 |
| Molecular Weight | 360.878 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Detection and measurement of the agonistic activities of PCBs and mono-hydroxylated PCBs to the constitutive androstane receptor using a recombinant yeast assay. | 2015-10 |
|
| Lactational exposure to low levels of the six indicator non-dioxin-like polychlorinated biphenyls induces DNA damage and repression of neuronal activity, in juvenile male mice. | 2015-02-03 |
|
| Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. | 2014-08-01 |
|
| Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes. | 2013-10-01 |
|
| Perinatal exposure to purity-controlled polychlorinated biphenyl 52, 138, or 180 alters toxicogenomic profiles in peripheral blood of rats after 4 months. | 2013-08-19 |
|
| Neurodevelopmental and behavioral toxicity via lactational exposure to the sum of six indicator non-dioxin-like-polychlorinated biphenyls (∑6 NDL-PCBs) in mice. | 2012-09-04 |
|
| Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner. | 2012-08-15 |
|
| Transcriptomics identifies differences between ultrapure non-dioxin-like polychlorinated biphenyls (PCBs) and dioxin-like PCB126 in cultured peripheral blood mononuclear cells. | 2011-09-05 |
|
| Cerebellum proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138. | 2011-09 |
|
| In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. | 2011-09 |
|
| In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans. | 2011-05 |
|
| Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus. | 2011-04-01 |
|
| Endocrine disruption of brain sexual differentiation by developmental PCB exposure. | 2011-02 |
|
| In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. | 2011-01 |
|
| Photocatalytic dechlorination of PCB 138 using leuco-methylene blue and visible light; reaction conditions and mechanisms. | 2010-09-15 |
|
| DDE in mothers' blood during pregnancy and lower respiratory tract infections in their infants. | 2010-09 |
|
| Developmental exposure to polychlorinated biphenyls 52, 138 or 180 affects differentially learning or motor coordination in adult rats. Mechanisms involved. | 2010-06-02 |
|
| Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. | 2010-04-19 |
|
| Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples. | 2010-01 |
|
| Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells. | 2009-12-10 |
|
| Factorial design applied for multiple endpoint toxicity evaluation in Atlantic salmon (Salmo salar L.) hepatocytes. | 2009-12 |
|
| Transactivation potencies of Baikal seal constitutive active/androstane receptor by persistent organic pollutants and brominated flame retardants. | 2009-08-15 |
|
| Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 2: Effects on reproductive parameters, on sex behavior, on memory retention and on hypothalamic expression of aromatase and 5alpha-reductases in the offspring. | 2009-08-15 |
|
| Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring. | 2009-06-01 |
|
| A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies. | 2009-03 |
|
| Serum concentrations of indicator PCB congeners in the Czech adult population. | 2008-07 |
|
| Different effects of PCB101, PCB118, PCB138 and PCB153 alone or mixed in MCF-7 breast cancer cells. | 2008-07 |
|
| Pesticide contamination profiles of water, sediment and aquatic organisms in the effluent of Gaobeidian wastewater treatment plant. | 2008-07 |
|
| Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008-04 |
|
| Photocatalysis of 2,2',3,4,4',5'-hexachlorobiphenyl and its intermediates using various catalytical preparing methods. | 2006-08-25 |
|
| A PCR-based specific assay reveals a population of bacteria within the Chloroflexi associated with the reductive dehalogenation of polychlorinated biphenyls. | 2005-06 |
|
| Species differences in the tissue distribution of catechol and methylsulphonyl metabolites of 2,4,5,2',5'-penta- and 2,3,4,2',3',6'-hexachlorobiphenyls in rats, mice, hamsters and guinea pigs. | 2005-01 |
|
| Retention indexes for temperature-programmed gas chromatography of polychlorinated biphenyls. | 2004-09-15 |
|
| Lineage-specific effects of polychlorinated biphenyls (PCB) on gene expression in the rabbit blastocyst. | 2004-04-08 |
|
| Tumor promoters as inhibitors of apoptosis in rat hepatocytes. | 2004-04-01 |
|
| Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts. | 2003-10-15 |
|
| The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE. | 2003-09 |
|
| Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone binding. | 2002-03-15 |
|
| Inhibition of E2-induced expression of BRCA1 by persistent organochlorines. | 2002 |
|
| [Species differences in the in vitro metabolism of 2,4,5,2',3',4'-hexachlorobiphenyl]. | 2001-05 |
|
| Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. | 2001-02-14 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:45:22 GMT 2025
by
admin
on
Mon Mar 31 21:45:22 GMT 2025
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| Record UNII |
7Y6JIG1867
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID8038300
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7Y6JIG1867
Created by
admin on Mon Mar 31 21:45:22 GMT 2025 , Edited by admin on Mon Mar 31 21:45:22 GMT 2025
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