PROSPIDIUM

Details

Stereochemistry	UNKNOWN
Molecular Formula	C18H36Cl2N4O2
Molecular Weight	411.41
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	2

SHOW SMILES / InChI

Structure Search

SMILES

OC(CCl)CN1CC[N+]2(CC1)CC[N+]3(CCN(CC(O)CCl)CC3)CC2

InChI

InChIKey=UVYDWIMQPVNRJN-UHFFFAOYSA-N

InChI=1S/C18H36Cl2N4O2/c19-13-17(25)15-21-1-5-23(6-2-21)9-11-24(12-10-23)7-3-22(4-8-24)16-18(26)14-20/h17-18,25-26H,1-16H2/q+2

HIDE SMILES / InChI

Molecular Formula	C18H34Cl2N4O2
Molecular Weight	409.394
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6225629 | https://www.ncbi.nlm.nih.gov/pubmed/7315580 | https://www.ncbi.nlm.nih.gov/pubmed/6571330

Prospidium is a diazoniadispiro(5.2.5.2)hexadecane derivative patented by All-Union Scientific-Research Chemical-Pharmaceutical Institute as an antitumor agent that does not inhibit hematopoiesis. In preclinical models, The injection of Prospidium to thyroidectomized and hypophysectomized rats inhibited tumor growth to a greater extent than in intact rats. Larynx and lung cancer, lymphogranulomatosis, leucosis, etc. can be successfully treated with Prospidium at doses of 60-120 mg daily.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:33:15 GMT 2023` Edited by `admin` on `Fri Dec 15 15:33:15 GMT 2023`
Record UNII	7Y2M0915RZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROSPIDIUM

Common Name

English

PROSPIDIUM CATION

Common Name

English

PROSPIDIUM ION

Common Name

English

3,12-BIS(3-CHLORO-2-HYDROXYPROPYL)-3,12-DIAZA-6,9-DIAZONIADISPIRO(5.2.5.2)HEXADECANE

Systematic Name

English

Prospidium [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C574