Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C12H15Cl2NO |
| Molecular Weight | 260.16 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(C)C(=O)NC1=CC(Cl)=C(Cl)C=C1
InChI
InChIKey=VUNCGGHZBFQRPB-UHFFFAOYSA-N
InChI=1S/C12H15Cl2NO/c1-3-4-8(2)12(16)15-9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
| Molecular Formula | C12H15Cl2NO |
| Molecular Weight | 260.16 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Effectiveness of legalon and essentiale in a tetracycline-induced liver lesion]. | 1986 Oct |
|
| Cytotoxicity of inorganic mercury in murine T and B lymphoma cell lines: involvement of reactive oxygen species, Ca(2+) homeostasis, and cytokine gene expression. | 2003 Aug |
|
| Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats. | 2006 May |
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| Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride. | 2007 Aug |
|
| Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. | 2007 Feb |
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| Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: involvement of inducible nitric oxide synthase and hemoxygenase-1. | 2009 Feb |
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| Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles. | 2010 Jun |
|
| Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro. | 2010 Mar |
|
| Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study. | 2010 Sep 1 |
|
| Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice. | 2011 Feb 4 |
|
| Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity. | 2012 Mar |
|
| Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line. | 2012 Sep |
|
| Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | 2013 Dec |
|
| Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism. | 2013 Dec |
|
| Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice. | 2015 Jun 25 |
|
| Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. | 2015 Nov 15 |
|
| Effects of Melatonin-Aided Therapy on the Glutathione Antioxidant System Activity and Liver Protection. | 2015 Oct |
|
| Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway. | 2015 Oct 5 |
|
| Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. | 2015 Sep 17 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 02:17:55 GMT 2023
by
admin
on
Sat Dec 16 02:17:55 GMT 2023
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| Record UNII |
7WAZ49QYN0
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| Record Status |
Validated (UNII)
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| Record Version |
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m6603
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