Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H21N3O6S |
| Molecular Weight | 335.377 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O
InChI
InChIKey=HMFDVPSBWOHOAP-YUMQZZPRSA-N
InChI=1S/C12H21N3O6S/c1-2-22-6-8(11(19)14-5-10(17)18)15-9(16)4-3-7(13)12(20)21/h7-8H,2-6,13H2,1H3,(H,14,19)(H,15,16)(H,17,18)(H,20,21)/t7-,8-/m0/s1
| Molecular Formula | C12H21N3O6S |
| Molecular Weight | 335.377 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Decreased levels of total and reduced glutathione in CD4+ lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor system: possible immunopathogenic role of oxidative stress. | 1995 Aug 15 |
|
| IL-4 gene expression up-regulated by mercury in rat mast cells: a role of oxidant stress in IL-4 transcription. | 2001 Mar |
|
| Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. | 2002 Jul |
|
| Mediation of cadmium-induced oxidative damage and glucose-6-phosphate dehydrogenase expression through glutathione depletion. | 2003 |
|
| Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects. | 2003 Apr |
|
| Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. | 2003 Jun |
|
| Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells. | 2004 Jul 2 |
|
| Inducible nitric oxide synthase up-regulation and mitochondrial glutathione depletion mediate cyanide-induced necrosis in mesencephalic cells. | 2006 Oct |
|
| Investigation of bioactivation and toxicity of styrene in CYP2E1 transgenic cells. | 2006 Sep 21 |
|
| Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress. | 2007 Jul 3 |
|
| Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid. | 2008 Feb 1 |
|
| Manganese inhibits the ability of astrocytes to promote neuronal differentiation. | 2009 Oct 15 |
|
| The critical role of the cellular thiol homeostasis in cadmium perturbation of the lung extracellular matrix. | 2010 Jan 12 |
|
| Modulation of intracellular glutathione affects adipogenesis in 3T3-L1 cells. | 2011 Aug |
|
| Redox state alters anti-cancer effects of wedelolactone. | 2012 Aug |
|
| The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells. | 2013 Sep 25 |
|
| Diethyl maleate inhibits MCA+TPA transformed cell growth via modulation of GSH, MAPK, and cancer pathways. | 2014 Aug 5 |
|
| 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression. | 2015 Feb 25 |
|
| Targeting oxidative stress in the hypothalamus: the effect of transcription factor STAT3 knockdown on endogenous antioxidants-mediated appetite control. | 2015 Jan |
|
| Involvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats. | 2015 May |
|
| Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter. | 2015 Sep 17 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:49:17 GMT 2023
by
admin
on
Sat Dec 16 05:49:17 GMT 2023
|
| Record UNII |
7W95D60F4J
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID40179183
Created by
admin on Sat Dec 16 05:49:17 GMT 2023 , Edited by admin on Sat Dec 16 05:49:17 GMT 2023
|
PRIMARY | |||
|
7W95D60F4J
Created by
admin on Sat Dec 16 05:49:17 GMT 2023 , Edited by admin on Sat Dec 16 05:49:17 GMT 2023
|
PRIMARY | |||
|
107650
Created by
admin on Sat Dec 16 05:49:17 GMT 2023 , Edited by admin on Sat Dec 16 05:49:17 GMT 2023
|
PRIMARY | |||
|
24425-52-3
Created by
admin on Sat Dec 16 05:49:17 GMT 2023 , Edited by admin on Sat Dec 16 05:49:17 GMT 2023
|
PRIMARY |