Details
Stereochemistry | RACEMIC |
Molecular Formula | C8H11NO3.ClH |
Molecular Weight | 205.639 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NCC(O)C1=CC(O)=C(O)C=C1
InChI
InChIKey=FQTFHMSZCSUVEU-UHFFFAOYSA-N
InChI=1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C8H11NO3 |
Molecular Weight | 169.1778 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Norepinephrine hydrochloride, (±)- (DL-Norepinephrine Hydrochloride) is a vasoconstrictor, cardiac stimulant, α- and β-sympathomimetic agent. DL-Norepinephrine hydrochloride is an adrenergic drug. Norepinephrine is an endogenous catecholamine that is the neurotransmitter at sympathetic postganglionic fibers. It has potent beta1- and alpha-stimulating effects. In contrast to epinephrine, norepinephrine has only minor effects on beta2 receptors. The clinical effects of norepinephrine administration are mainly increased cardiac index and increased vascular (systemic and pulmonary) resistance. Several adult studies have suggested that norepinephrine is useful in increasing SVR in patients with hyperdynamic or vasodilatory septic shock that is not responsive to dopamine or epinephrine. Additionally, it can augment coronary blood flow by increasing systemic diastolic pressure, at the expense of increasing afterload.
Approval Year
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2989425
Curator's Comment: The functional significance of beta 2-adrenoceptors in atrioventricular (AV) nodal conduction was investigated by using canine isolated blood-perfused AV node preparations. The dose-response curve for dl-norepinephrine (0.03-1 nmol) was shifted to the right by 1.0 log unit with atenolol only. https://www.ncbi.nlm.nih.gov/pubmed/1346356
The biogenic amines DL-epinephrine, DL-norepinephrine, tyramine, DL-phenylethanolamine, 2-phenylethylamine, and dopamine, applied at concentrations of 10(-8) or 10(-4) M, do not change the MFF (maximum following frequency, MFF).
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:04:46 GMT 2023
by
admin
on
Sat Dec 16 08:04:46 GMT 2023
|
Record UNII |
7W3827X38V
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
55-27-6
Created by
admin on Sat Dec 16 08:04:46 GMT 2023 , Edited by admin on Sat Dec 16 08:04:46 GMT 2023
|
PRIMARY | |||
|
7W3827X38V
Created by
admin on Sat Dec 16 08:04:46 GMT 2023 , Edited by admin on Sat Dec 16 08:04:46 GMT 2023
|
PRIMARY | |||
|
7930
Created by
admin on Sat Dec 16 08:04:46 GMT 2023 , Edited by admin on Sat Dec 16 08:04:46 GMT 2023
|
PRIMARY | |||
|
200-229-8
Created by
admin on Sat Dec 16 08:04:46 GMT 2023 , Edited by admin on Sat Dec 16 08:04:46 GMT 2023
|
PRIMARY | |||
|
5923
Created by
admin on Sat Dec 16 08:04:46 GMT 2023 , Edited by admin on Sat Dec 16 08:04:46 GMT 2023
|
PRIMARY |