N-(6-METHOXY-8-QUINOLYL)-4-TOLUENESULFONAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16N2O3S
Molecular Weight	328.386
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of N-(6-METHOXY-8-QUINOLYL)-4-TOLUENESULFONAMIDE

Structure Search

SMILES

COC1=CC2=CC=CN=C2C(NS(=O)(=O)C3=CC=C(C)C=C3)=C1

InChI

InChIKey=HKRNYOZJJMFDBV-UHFFFAOYSA-N

InChI=1S/C17H16N2O3S/c1-12-5-7-15(8-6-12)23(20,21)19-16-11-14(22-2)10-13-4-3-9-18-17(13)16/h3-11,19H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H16N2O3S
Molecular Weight	328.386
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel.	2010-11-05	20864526
Secretory state regulates Zn2+ transport in gastric parietal cell of the rabbit.	2009-10	19675302
Role of zinc finger structure in nuclear localization of transcription factor Sp1.	2009-02-27	19138671
Changes in metallothionein levels in freshwater mussels exposed to urban wastewaters: effects from exposure to heavy metals?	2007-03-29	19662196
Silica nanoparticles for fluorescence sensing of Zn(II): exploring the covalent strategy.	2007	17154317
Neurotoxic zinc translocation into hippocampal neurons is inhibited by hypothermia and is aggravated by hyperthermia after traumatic brain injury in rats.	2006-02	15988476
Tetanically released zinc inhibits hippocampal mossy fiber calcium, zinc and synaptic responses.	2005-06-14	15950598
Measurement of presynaptic zinc changes in hippocampal mossy fibers.	2004-11-05	15476692
Zinc release contributes to hypoglycemia-induced neuronal death.	2004-08	15262265
Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells.	2004-03-01	14629198
Clioquinol effects on tissue chelatable zinc in mice.	2003-10	12928783
Role of metallothionein in regulating the abundance of histochemically reactive zinc in rat tissues.	2003-08	12897811
Expression of P2X6, a purinergic receptor subunit, is affected by dietary zinc deficiency in rat hippocampus.	2003-01	12713031
Modulation of energy metabolism in c6 glioma cells as possible mechanism contributing to zinc neurotoxicity.	2003	20021152
Mild hypothermia reduces zinc translocation, neuronal cell death, and mortality after transient global ischemia in mice.	2002-10	12368662
Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain.	2002-06-03	11984815
Trans-synaptic increase of hypoxic tolerance in hippocampus upon physical challenge with two-photon microscopy.	2002	12542228
Zinc translocation accelerates infarction after mild transient focal ischemia.	2002	12435425
Nitric oxide causes apparent release of zinc from presynaptic boutons.	2002	12421613
Imaging synaptic zinc release in living nervous tissue.	2001-09-30	11564525
Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine.	2001-05-25	11388441
Zinc co-localizes with GABA and glycine in synapses in the lamprey spinal cord.	2001-04-30	11283960

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:09:44 GMT 2025` Edited by `admin` on `Mon Mar 31 19:09:44 GMT 2025`
Record UNII	7SWW052N6R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TSQ	Locators: MI Sources:

Preferred Name

English

N-(6-METHOXY-8-QUINOLYL)-4-TOLUENESULFONAMIDE

Systematic Name

English

TSQ [MI]

Common Name

English

6-METHOXY-8-(P-TOLUENESULFONYL)AMINOQUINOLINE

Common Name

English

N-(6-METHOXY-8-QUINOLINYL)-4-METHYLBENZENESULFONAMIDE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID00148996