Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H14N4O2.C6H10O3 |
| Molecular Weight | 304.3428 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)CC(=O)C(O)=O.N[C@@H](CCCNC(N)=N)C(O)=O
InChI
InChIKey=MOZIGXHKOXEDLJ-WCCKRBBISA-N
InChI=1S/C6H14N4O2.C6H10O3/c7-4(5(11)12)2-1-3-10-6(8)9;1-4(2)3-5(7)6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);4H,3H2,1-2H3,(H,8,9)/t4-;/m0./s1
| Molecular Formula | C6H10O3 |
| Molecular Weight | 130.1418 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H14N4O2 |
| Molecular Weight | 174.201 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Differential acute and long term actions of succinic acid monomethyl ester exposure on insulin-secreting BRIN-BD11 cells. | 2001 |
|
| Effects of dietary protein restriction and amino acids deficiency on protein metabolism in dogs. | 2001 Aug |
|
| Psychrophilic valine dehydrogenase of the antarctic psychrophile, Cytophaga sp. KUC-1: purification, molecular characterization and expression. | 2001 Aug |
|
| Recovery of (13)CO(2) from infused [1-(13)C]leucine and [1,2-(13)C(2)]leucine in healthy humans. | 2001 Aug |
|
| Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats. | 2001 Dec |
|
| Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin. | 2001 Dec |
|
| Modulation of absence seizures by branched-chain amino acids: correlation with brain amino acid concentrations. | 2001 Jul |
|
| TPN-evoked dysfunction of islet lysosomal activity mediates impairment of glucose-stimulated insulin release. | 2001 Jul |
|
| Leucine and its keto acid enhance the coordinated expression of genes for branched-chain amino acid catabolism in Arabidopsis under sugar starvation. | 2001 Jun 15 |
|
| Structures of Escherichia coli branched-chain amino acid aminotransferase and its complexes with 4-methylvalerate and 2-methylleucine: induced fit and substrate recognition of the enzyme. | 2001 Jun 26 |
|
| Recovery of function and mass of endogenous beta-cells in streptozotocin-induced diabetic rats treated with islet transplantation. | 2001 Sep 14 |
|
| Supplementing with beta-hydroxy-beta-methylbutyrate (HMB) to build and maintain muscle mass: a review. | 2002 |
|
| Increased synthesis rate of fibrinogen as a basis for its elevated plasma levels in obese female adolescents. | 2002 Apr |
|
| Effects of leucine supplemented diet on intestinal absorption in tumor bearing pregnant rats. | 2002 Apr 15 |
|
| Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes. | 2002 Aug |
|
| Insulin secretion induced by palmitate--a process fully dependent on glucose concentration. | 2002 Dec |
|
| Kinetics of sequential metabolism from D-leucine to L-leucine via alpha-ketoisocaproic acid in rat. | 2002 Dec |
|
| Role of blood cells in leucine kinetics across the human kidney. | 2002 Dec |
|
| alpha-Ketoisocaproic acid regulates phosphorylation of intermediate filaments in postnatal rat cortical slices through ionotropic glutamatergic receptors. | 2002 Dec 15 |
|
| Leucine promotes glucose uptake in skeletal muscles of rats. | 2002 Dec 20 |
|
| Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon. | 2002 Feb |
|
| Protein turnover, lipolysis, and endogenous hormonal secretion in critically ill children. | 2002 Jan |
|
| The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat islets. | 2002 Jan |
|
| Short-term treatment with low doses of recombinant human GH stimulates lipolysis in visceral obese men. | 2002 Jul |
|
| Effect of the branched-chain alpha-ketoacids accumulating in maple syrup urine disease on the high molecular weight neurofilament subunit (NF-H) in rat cerebral cortex. | 2002 Jun |
|
| Effects of medium- and long-chain fatty acids on whole body leucine and glucose kinetics in man. | 2002 Jun |
|
| Effect of supply of metabolizable protein on whole body and splanchnic leucine metabolism in lactating dairy cows. | 2002 Oct |
|
| The stimulus-secretion coupling of amino acid-induced insulin release. Insulinotropic action of L-alanine. | 2002 Oct 10 |
|
| In vivo assessment of the mitochondrial response to caloric restriction in obese women by the 2-keto[1-C]isocaproate breath test. | 2003 Apr |
|
| Acute effects of acidosis on protein and amino acid metabolism in perfused rat liver. | 2003 Aug |
|
| Metabolism of brain amino acids following pentylenetetrazole treatment. | 2003 Feb |
|
| Disturbance of cultured rat neuronal network activity depends on concentration and ratio of leucine and alpha-ketoisocaproate: implication for acute encephalopathy of maple syrup urine disease. | 2003 Feb |
|
| Effect of minimal enteral feeding on splanchnic uptake of leucine in the postabsorptive state in preterm infants. | 2003 Feb |
|
| Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids. | 2003 Jan 14 |
|
| Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation. | 2003 Jan 15 |
|
| Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of beta-decarboxylating dehydrogenase. | 2003 Jan 17 |
|
| Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. | 2003 Jan 31 |
|
| Opposite effects of glucose on plasma membrane Ca2+-ATPase and Na/Ca exchanger transcription, expression, and activity in rat pancreatic beta-cells. | 2003 Jun 20 |
|
| Effects of environmental factors on leucine catabolism by Carnobacterium piscicola. | 2003 Mar 25 |
|
| Oxidation of essential amino acids by the ovine gastrointestinal tract. | 2003 May |
|
| Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells. | 2003 May |
|
| Expression of monocarboxylic acid transporters (MCT) in brain cells. Implication for branched chain alpha-ketoacids transport in neurons. | 2003 Sep-Oct |
|
| Catabolism of leucine to branched-chain fatty acids in Staphylococcus xylosus. | 2004 |
|
| Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography. | 2004 Apr 2 |
|
| Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification. | 2004 Aug 24 |
|
| Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 beta-cells. | 2004 Feb |
|
| Nutritional supplementation acutely increases albumin fractional synthetic rate in chronic hemodialysis patients. | 2004 Jul |
|
| Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. | 2004 Jul |
|
| Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis. | 2004 Jun |
|
| Chemical conversion of alpha-keto acids in relation to flavor formation in fermented foods. | 2004 Mar 10 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:38:35 GMT 2023
by
admin
on
Sat Dec 16 10:38:35 GMT 2023
|
| Record UNII |
7S4R4V1RM7
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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| Classification Tree | Code System | Code | ||
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DSLD |
3836 (Number of products:4)
Created by
admin on Sat Dec 16 10:38:35 GMT 2023 , Edited by admin on Sat Dec 16 10:38:35 GMT 2023
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DSLD |
2700 (Number of products:4)
Created by
admin on Sat Dec 16 10:38:35 GMT 2023 , Edited by admin on Sat Dec 16 10:38:35 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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72087-40-2
Created by
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PRIMARY | |||
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DTXSID90992809
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353624
Created by
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22812595
Created by
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276-326-4
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7S4R4V1RM7
Created by
admin on Sat Dec 16 10:38:35 GMT 2023 , Edited by admin on Sat Dec 16 10:38:35 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |
