Details
Stereochemistry | MIXED |
Molecular Formula | C38H54O7.2Na |
Molecular Weight | 668.8107 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 9 / 11 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)[C@]4([H])[C@@]5(C)CC[C@H](OC(=O)C6CCCCC6C([O-])=O)C(C)(C)[C@]5([H])CC[C@@]34C)C([O-])=O
InChI
InChIKey=TYMKTTKIVJPCOT-OHDBHOPNSA-L
InChI=1S/C38H56O7.2Na/c1-33(2)27-12-15-38(7)29(36(27,5)14-13-28(33)45-31(42)23-11-9-8-10-22(23)30(40)41)26(39)20-24-25-21-35(4,32(43)44)17-16-34(25,3)18-19-37(24,38)6;;/h20,22-23,25,27-29H,8-19,21H2,1-7H3,(H,40,41)(H,43,44);;/q;2*+1/p-2/t22?,23?,25-,27-,28-,29+,34+,35-,36-,37+,38+;;/m0../s1
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C38H54O7 |
Molecular Weight | 622.8312 |
Charge | -2 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 9 / 11 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Cicloxolone is a broad spectrum antiviral agent with a largely non-specific and complex mode of antiviral action. The drug was active during all stages of the virus replication cycle, indicating that it does not operate by the specific inhibition of any single essential virus gene product. The drug reduced the number of vesicular stomatitis virusparticles assembled and released by 100- to 1000-fold. Infectious virus yield was reduced 1000- to 10000-fold, giving a 10-fold or greater increase in the particle/p.f.u. ratio. The reduced number of virus particles produced in the presence of Cicloxolone results from two superimposed effects: suppression of vesicular stomatitis virussecondary transcription and viral protein synthesis, and perturbation of virion assembly.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:10:00 GMT 2023
by
admin
on
Sat Dec 16 19:10:00 GMT 2023
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Record UNII |
7S0509075P
|
Record Status |
Validated (UNII)
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Record Version |
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-
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Code | English |
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61435-39-0
Created by
admin on Sat Dec 16 19:10:00 GMT 2023 , Edited by admin on Sat Dec 16 19:10:00 GMT 2023
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PRIMARY | |||
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124037370
Created by
admin on Sat Dec 16 19:10:00 GMT 2023 , Edited by admin on Sat Dec 16 19:10:00 GMT 2023
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PRIMARY | |||
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7S0509075P
Created by
admin on Sat Dec 16 19:10:00 GMT 2023 , Edited by admin on Sat Dec 16 19:10:00 GMT 2023
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PRIMARY |