Solbinsiran

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 10:00:38 GMT 2025` Edited by `admin` on `Wed Apr 02 10:00:38 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	7RRX3XD4VY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Solbinsiran

Official Name

English

LY-3561774

Preferred Name

English

RNA, ([4?-de(hydroxymethyl)-4?-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2?-deoxy-2?-fluoro)G-sp-(2?-deoxy-2?-fluoro)U-sp-(2?-deoxy-2?-fluoro)A-(2?-deoxy-2?-fluoro)U-Am-(2?-deoxy-2?-fluoro)A-Cm-Cm-(2?-deoxy-2?-fluoro)U-Um-Cm-Cm-(2?-deoxy-2?-fluoro)A-Um-

Systematic Name

English

solbinsiran [INN]

Common Name

English

LY3561774

Code

English

Code System Code Type Description

SMS_ID

300000040229

Created by admin on Wed Apr 02 10:00:38 GMT 2025 , Edited by admin on Wed Apr 02 10:00:38 GMT 2025

PRIMARY

INN

12626

Created by admin on Wed Apr 02 10:00:38 GMT 2025 , Edited by admin on Wed Apr 02 10:00:38 GMT 2025

PRIMARY

NCI_THESAURUS

C203139

Created by admin on Wed Apr 02 10:00:38 GMT 2025 , Edited by admin on Wed Apr 02 10:00:38 GMT 2025

PRIMARY

FDA UNII

7RRX3XD4VY

Created by admin on Wed Apr 02 10:00:38 GMT 2025 , Edited by admin on Wed Apr 02 10:00:38 GMT 2025

PRIMARY

CAS

2718150-11-7

Created by admin on Wed Apr 02 10:00:38 GMT 2025 , Edited by admin on Wed Apr 02 10:00:38 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_7;1_12-1_36;2_1;2_6;2_8-2_9;2_11-2_13;2_15-2_22	47 / 58
2'-Fluoro-Ribose	1_8-1_11;2_2-2_5;2_7;2_10;2_14	11 / 58

Linkage	Site Range	Site Count
Phosphate	1_3-1_36;2_5-2_19;2_22	50 / 56
Phosporothioate	1_2;2_2-2_4;2_20-2_21	6 / 56

Related Record Type Details


					7RRX3XD4VY

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_28] [1_29] [1_30]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	3a625511 (not in database)
NUCLEOTIDE SUBSTITUTION	[2_1]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	55513d6d (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL