MOVRONERSEN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 12:22:49 GMT 2025` Edited by `admin` on `Wed Apr 02 12:22:49 GMT 2025`
Record UNII	7RC7D4E8TD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MOVRONERSEN

Official Name

English

ALL-P-AMBO-2'-O-(2-METHOXYETHYL)-P-THIOADENYLYL-(3'->5')-2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDYLYL-(3'->5')-2'-O-(2-METHOXYETHYL)-P-THIOADENYLYL-(3'->5')-2'-O-(2-METHOXYETHYL)-P-THIOGUANYLYL-(3'->5')-2'-O-(2-METHOXYETHYL)-P-THIOADENYLYL-(3'->5')-P-THIOTHYM

Preferred Name

English

DNA, D((2'-O-(2-METHOXYETHYL))RA-SP-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-SP-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RA-SP-T-SP-A-SP-T-SP-T-SP-T-SP-T-SP-T-SP-G-SP-T-SP-T-SP-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5

Common Name

English

movronersen [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000052498

Created by admin on Wed Apr 02 12:22:49 GMT 2025 , Edited by admin on Wed Apr 02 12:22:49 GMT 2025

PRIMARY

FDA UNII

7RC7D4E8TD

Created by admin on Wed Apr 02 12:22:49 GMT 2025 , Edited by admin on Wed Apr 02 12:22:49 GMT 2025

PRIMARY

INN

11722

Created by admin on Wed Apr 02 12:22:49 GMT 2025 , Edited by admin on Wed Apr 02 12:22:49 GMT 2025

PRIMARY

NCI_THESAURUS

C184924

Created by admin on Wed Apr 02 12:22:49 GMT 2025 , Edited by admin on Wed Apr 02 12:22:49 GMT 2025

PRIMARY

CAS

2411937-33-0

Created by admin on Wed Apr 02 12:22:49 GMT 2025 , Edited by admin on Wed Apr 02 12:22:49 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_2;1_4-1_16;1_19-1_20	16 / 19
Phosphate	1_3;1_17-1_18	3 / 19

Related Record Type Details


					L9E2OD8XIY

ALPHA-SYNUCLEIN

TARGET->INHIBITOR OF EXPRESSION

Amount:

Related Record Type Details


					7RC7D4E8TD

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_2] [1_16] [1_19] [1_20]	SITE_SPECIFIC			5-METHYLCYTOSINE	6R795CQT4H
NUCLEOSIDE BASE SUBSTITUTION	[1_17]	SITE_SPECIFIC			THYMINE	QR26YLT7LT