Tazlestobart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:38:41 GMT 2025` Edited by `admin` on `Wed Apr 02 19:38:41 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	7QW97A6ZTH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tazlestobart

Common Name

English

H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-30*01 (94.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v6 CH2 A85.4, A118, A119 (CH1 R120 (215)

Preferred Name

English

Immunoglobulin G1 [299-alanine,334-alanine,335-alanine], anti-(human cytotoxic T-lymphocyte-associated protein 4) (human-Mus musculus monoclonal IMM27M ?-chain), disulfide with human-Mus musculus monoclonal IMM27M ?-chain, dimer

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4 (cytotoxic Tlymphocyte associated protein 4, CTLA-4, CD152)], humanized monoclonal antibody

Common Name

English

tazlestobart [INN]

Common Name

English

Code System Code Type Description

FDA UNII

7QW97A6ZTH

Created by admin on Wed Apr 02 19:38:41 GMT 2025 , Edited by admin on Wed Apr 02 19:38:41 GMT 2025

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CAS

2850355-80-3

Created by admin on Wed Apr 02 19:38:41 GMT 2025 , Edited by admin on Wed Apr 02 19:38:41 GMT 2025

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INN

12964

Created by admin on Wed Apr 02 19:38:41 GMT 2025 , Edited by admin on Wed Apr 02 19:38:41 GMT 2025

PRIMARY

NCI_THESAURUS

C207001

Created by admin on Wed Apr 02 19:38:41 GMT 2025 , Edited by admin on Wed Apr 02 19:38:41 GMT 2025

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SMS_ID

300000054736

Created by admin on Wed Apr 02 19:38:41 GMT 2025 , Edited by admin on Wed Apr 02 19:38:41 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_215
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_89
3_135	3_195
4_23	4_89
4_135	4_195
1_221	3_215
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					KYU4T5WAI2

CYTOTOXIC T-LYMPHOCYTE PROTEIN 4

TARGET->LIGAND

Amount:

Related Record Type Details


					7QW97A6ZTH

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL