Approval Year
| Substance Class |
Concept
|
| Record UNII |
7PO9B4VQ1U
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C129822
Created by
admin on Sat Dec 16 14:30:50 UTC 2023 , Edited by admin on Sat Dec 16 14:30:50 UTC 2023
|
||
|
NCI_THESAURUS |
C20401
Created by
admin on Sat Dec 16 14:30:50 UTC 2023 , Edited by admin on Sat Dec 16 14:30:50 UTC 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C132266
Created by
admin on Sat Dec 16 14:30:50 UTC 2023 , Edited by admin on Sat Dec 16 14:30:50 UTC 2023
|
PRIMARY | |||
|
7PO9B4VQ1U
Created by
admin on Sat Dec 16 14:30:50 UTC 2023 , Edited by admin on Sat Dec 16 14:30:50 UTC 2023
|
PRIMARY |
This is a non-substance concept
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
Targets and binds to CD73, leading to clustering and internalization of CD73. This prevents CD73-mediated conversion of extracellular adenosine monophosphate (AMP) to adenosine and decreases the amount of free adenosine. This prevents adenosine-mediated suppression of lymphocyte activity and increases the activity of CD8-positive effector cells. This also activates macrophages, and reduces the activity of both myeloid-derived suppressor cells (MDSCs) and regulatory T-lymphocytes.
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
This is a non-substance concept