Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2Cl3O2.H4N |
| Molecular Weight | 180.418 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[NH4+].[O-]C(=O)C(Cl)(Cl)Cl
InChI
InChIKey=MHMUIIBVMBOAON-UHFFFAOYSA-N
InChI=1S/C2HCl3O2.H3N/c3-2(4,5)1(6)7;/h(H,6,7);1H3
| Molecular Formula | C2HCl3O2 |
| Molecular Weight | 163.387 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | H3N |
| Molecular Weight | 17.0305 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Trichloroacetic acid (TCA; TCAA) is a chemical used in skin peel formulations. It is more frequently used for lighter skin and is less used on darker skin because of the higher risks of scarring, as well as post-peel dyschromias. Low concentrations, 10-35% is preferred for skin peel formulations so that it only reaches the upper papillary dermis. Topical TCA is an efficacious treatment of internal anal high-grade squamous intraepithelial lesions (HSIL). Advantages of TCA for this recurrent disease process include low cost, no requirement for special equipment beyond that for high-resolution anoscopy, and painless application procedure.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. | 1999 Dec 1 |
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| Synthesis of disaccharides related to the mycobacterial arabinogalactan. | 2001 |
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| Deproteinization of serum: another best approach to eliminate all forms of bilirubin interference on serum creatinine by the kinetic Jaffe reaction. | 2001 |
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| The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice. | 2001 |
|
| ATP inhibits insulin-degrading enzyme activity. | 2001 Apr |
|
| The effects of alpha-lactabumin and whey protein concentrate on dry matter recovery, TCA soluble protein levels, and peptide distribution in the rat gastrointestinal tract. | 2001 Apr |
|
| Trimethylamine and total volatile basic nitrogen determination by flow injection/gas diffusion in Mediterranean hake (Merluccius merluccius). | 2001 Apr |
|
| [Endogenic intoxication markers: data from capillary electrophoresis of trichloroacetic acid supernatant]. | 2001 Aug |
|
| Stability of a cisplatin-chondroitin sulfate A complex in plasma and kidney in terms of protein binding. | 2001 Aug |
|
| Production of hyaluronan and chondroitin sulphate proteoglycans from human arterial smooth muscle--the effect of glucose, insulin, IGF-I or growth hormone. | 2001 Aug |
|
| Assay of 2,3-dihydroxybenzoic acid and related compounds in plant materials by high-performance liquid chromatography. | 2001 Aug 24 |
|
| Factors involved in clearance of genital warts. | 2001 Dec |
|
| Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway. | 2001 Dec |
|
| A novel method to analyze betaine in chicken liver: effect of dietary betaine and choline supplementation on the hepatic betaine concentration in broiler chicks. | 2001 Feb |
|
| Simple and rapid determination of nevirapine in human serum by reversed-phase high-performance liquid chromatography. | 2001 Feb 25 |
|
| Isolation of antidiabetic components from white-skinned sweet potato (Ipomoea batatas L.). | 2001 Jan |
|
| Insulin receptor antibodies inhibit insulin uptake by the liver: in vivo 123I-insulin scintigraphic scanning and in vitro characterization in autoimmune hypoglycemia. | 2001 Jan |
|
| Medium-depth chemical peels. | 2001 Jul |
|
| Dermal peels. | 2001 Jul |
|
| A simple HPLC method for the determination of the mycotoxins ochratoxin A and B in blood serum of swine. | 2001 Jul |
|
| Factors influencing attachment of thermophilic bacilli to stainless steel. | 2001 Jun |
|
| Direct electrochemistry of hemoglobin in layer-by-layer films with poly(vinyl sulfonate) grown on pyrolytic graphite electrodes. | 2001 Mar |
|
| Inositol phosphates from barley low-phytate grain mutants analysed by metal-dye detection HPLC and NMR. | 2001 Mar 1 |
|
| Leptin transport at the blood--cerebrospinal fluid barrier using the perfused sheep choroid plexus model. | 2001 Mar 23 |
|
| The treatment of eruptive syringomas in an African American patient with a combination of trichloroacetic acid and CO2 laser destruction. | 2001 May |
|
| How Ala-->Gly mutations in different helices affect the stability of the apomyoglobin molten globule. | 2001 May 1 |
|
| A facile and effective synthesis of alpha-(1-->6)-linked mannose di-, tri-, tetra-, hexa-, octa-, and dodecasaccharides, and beta-(1-->6)-linked glucose di-, tri-, tetra-, hexa-, and octasaccharides using sugar trichloroacetimidates as the donors and unprotected or partially protected glycosides as the acceptors. | 2001 May 8 |
|
| Differences in yields of microbial crude protein from in vitro fermentation of carbohydrates. | 2001 Nov |
|
| Antibodies against Streptococcus agalactiae proteins c(alpha) and R4 in sera from pregnant women from Norway and Zimbabwe. | 2001 Nov |
|
| Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation. | 2001 Nov 6 |
|
| New method for exopolysaccharide determination in culture broth using stirred ultrafiltration cells. | 2001 Oct |
|
| Glutathione stability in whole blood: effects of various deproteinizing acids. | 2001 Oct |
|
| Atomic emission method for total boron in blood during neutron-capture therapy. | 2001 Oct |
|
| Trace determination of 1-octacosanol in rat plasma by solid-phase extraction with Tenax GC and capillary gas chromatography. | 2001 Oct 5 |
|
| The immunosuppressive activity of chemically modified lipopolysaccharide of Shigella sonnei. | 2002 Jan 1 |
|
| Sources, pathways, and relative risks of contaminants in surface water and groundwater: a perspective prepared for the Walkerton inquiry. | 2002 Jan 11 |
Sample Use Guides
for melasma: 15% TCA peel
for anal high-grade squamous intraepithelial lesions: 80% TCA
Route of Administration:
Topical
Lymphocytes obtained from three healthy donors were exposed to 25, 50, and 100 μg/ml concentration of TCA separately. TCA exposure resulted in chromosomal anomalies and the formation of micronuclei in lymphocytes. Chromosome analysis revealed the dose-dependent and significant induction of Chromosomal aberration (CA).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 03:00:37 GMT 2023
by
admin
on
Sat Dec 16 03:00:37 GMT 2023
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| Record UNII |
7PL9R555XT
|
| Record Status |
Validated (UNII)
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| Record Version |
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EPA PESTICIDE CODE |
76801
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7PL9R555XT
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7646-88-0
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TCA-ammonium
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231-593-6
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DTXSID80897273
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24289
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