Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C19H22N4O3 |
Molecular Weight | 354.403 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(CC2=C(N)N=C(N)N=C2)=C3C=C[C@@H](OC3=C1OC)C4CC4
InChI
InChIKey=HWJPWWYTGBZDEG-CQSZACIVSA-N
InChI=1S/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)/t14-/m1/s1
Molecular Formula | C19H22N4O3 |
Molecular Weight | 354.403 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Aerie Pharmaceuticals, Inc. (Bridgewater, NJ), was developing a novel prostaglandin analog, AR-102, that had 150-fold greater selectivity and 30-fold greater potency at the FP receptor than latanoprost. In preclinical studies, the drug has shown greater IOP-lowering efficacy and alonger duration of action than latanoprost and betterocular tolerability than travoprost. AR-102 was in early-stage clinical development for glaucoma, which was discontinued later..
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Recently approved and investigational antibiotics for treatment of severe infections caused by Gram-positive bacteria. | 2005 Oct |
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Dihydrofolate reductase inhibitors as antibacterial agents. | 2006 Mar 30 |
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Gateways to clinical trials. | 2007 Dec |
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Effect of human plasma on the antimicrobial activity of iclaprim in vitro. | 2007 Dec |
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Investigational treatments for postoperative surgical site infections. | 2007 Feb |
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Activity of iclaprim against Legionella pneumophila. | 2007 Oct |
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Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (AR-100) in healthy men. | 2007 Sep |
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Alternatives to vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections. | 2007 Sep 15 |
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[New antimicrobials against Gram-positive organisms]. | 2008 |
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Investigational antimicrobial drugs for bloodstream infections. | 2008 Aug |
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What's new and not so new on the antimicrobial horizon? | 2008 Dec |
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Pharmacologic options for CNS infections caused by resistant Gram-positive organisms. | 2008 Feb |
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Iclaprim, a diaminopyrimidine dihydrofolate reductase inhibitor for the potential treatment of antibiotic-resistant staphylococcal infections. | 2008 Feb |
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Evidence based approach to the treatment of community-associated methicillin-resistant Staphylococcus aureus. | 2009 |
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New antimicrobial molecules and new antibiotic strategies. | 2009 Apr |
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Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity. | 2009 Apr |
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Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. | 2009 Aug |
|
New antimicrobial agents for methicillin-resistant Staphylococcus aureus. | 2009 Dec |
|
Future treatment options for Gram-positive infections--looking ahead. | 2009 Dec |
|
Activity of iclaprim against clinical isolates of Streptococcus pyogenes and Streptococcus agalactiae. | 2009 Feb |
|
Iclaprim: a novel dihydrofolate reductase inhibitor for skin and soft tissue infections. | 2009 Mar |
|
[Update on antimicrobial chemotherapy]. | 2010 Mar |
|
Mechanisms of resistance to antimicrobial drugs in pathogenic Gram-positive cocci. | 2010 Sep |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00523250
AR-102 0.003-0.03% Ophthalmic Solution
Route of Administration:
Topical
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:11:27 GMT 2023
by
admin
on
Sat Dec 16 11:11:27 GMT 2023
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Record UNII |
7P9VLC9Y9D
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Record Status |
Validated (UNII)
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Record Version |
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-
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44141864
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1208116-66-8
Created by
admin on Sat Dec 16 11:11:27 GMT 2023 , Edited by admin on Sat Dec 16 11:11:27 GMT 2023
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7P9VLC9Y9D
Created by
admin on Sat Dec 16 11:11:27 GMT 2023 , Edited by admin on Sat Dec 16 11:11:27 GMT 2023
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Related Record | Type | Details | ||
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ENANTIOMER -> ENANTIOMER |
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RACEMATE -> ENANTIOMER |
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