Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H22N4O3 |
| Molecular Weight | 354.403 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(CC2=C(N)N=C(N)N=C2)=C3C=C[C@@H](OC3=C1OC)C4CC4
InChI
InChIKey=HWJPWWYTGBZDEG-CQSZACIVSA-N
InChI=1S/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)/t14-/m1/s1
| Molecular Formula | C19H22N4O3 |
| Molecular Weight | 354.403 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Aerie Pharmaceuticals, Inc. (Bridgewater, NJ), was developing a novel prostaglandin analog, AR-102, that had 150-fold greater selectivity and 30-fold greater potency at the FP receptor than latanoprost. In preclinical studies, the drug has shown greater IOP-lowering efficacy and alonger duration of action than latanoprost and betterocular tolerability than travoprost. AR-102 was in early-stage clinical development for glaucoma, which was discontinued later..
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Investigational treatments for postoperative surgical site infections. | 2007 Feb |
|
| Alternatives to vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections. | 2007 Sep 15 |
|
| Current and novel antibiotics against resistant Gram-positive bacteria. | 2008 |
|
| [New antimicrobials against Gram-positive organisms]. | 2008 |
|
| Gateways to clinical trials. | 2008 Oct |
|
| Evidence based approach to the treatment of community-associated methicillin-resistant Staphylococcus aureus. | 2009 |
|
| Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. | 2009 Aug |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:11:27 GMT 2023
by
admin
on
Sat Dec 16 11:11:27 GMT 2023
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| Record UNII |
7P9VLC9Y9D
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| Record Status |
Validated (UNII)
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| Record Version |
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44141864
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1208116-66-8
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admin on Sat Dec 16 11:11:27 GMT 2023 , Edited by admin on Sat Dec 16 11:11:27 GMT 2023
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7P9VLC9Y9D
Created by
admin on Sat Dec 16 11:11:27 GMT 2023 , Edited by admin on Sat Dec 16 11:11:27 GMT 2023
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| Related Record | Type | Details | ||
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ENANTIOMER -> ENANTIOMER |
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RACEMATE -> ENANTIOMER |
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