Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H22N4O3 |
| Molecular Weight | 354.403 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(CC2=C(N)N=C(N)N=C2)=C3C=C[C@@H](OC3=C1OC)C4CC4
InChI
InChIKey=HWJPWWYTGBZDEG-CQSZACIVSA-N
InChI=1S/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)/t14-/m1/s1
| Molecular Formula | C19H22N4O3 |
| Molecular Weight | 354.403 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Aerie Pharmaceuticals, Inc. (Bridgewater, NJ), was developing a novel prostaglandin analog, AR-102, that had 150-fold greater selectivity and 30-fold greater potency at the FP receptor than latanoprost. In preclinical studies, the drug has shown greater IOP-lowering efficacy and alonger duration of action than latanoprost and betterocular tolerability than travoprost. AR-102 was in early-stage clinical development for glaucoma, which was discontinued later..
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Infections associated with orthopedic implants. | 2006 Aug |
|
| Antibacterial drug discovery and development--SRI's 11th Annual Summit. Antibacterial trends and current research. | 2006 Jun |
|
| Gateways to clinical trials. | 2007 Dec |
|
| Activity of iclaprim against Legionella pneumophila. | 2007 Oct |
|
| Iclaprim. | 2007 Sep |
|
| Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (AR-100) in healthy men. | 2007 Sep |
|
| Alternatives to vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections. | 2007 Sep 15 |
|
| Current and novel antibiotics against resistant Gram-positive bacteria. | 2008 |
|
| Investigational antimicrobial drugs for bloodstream infections. | 2008 Aug |
|
| What's new and not so new on the antimicrobial horizon? | 2008 Dec |
|
| A review of telavancin in the treatment of complicated skin and skin structure infections (cSSSI). | 2008 Feb |
|
| Pharmacologic options for CNS infections caused by resistant Gram-positive organisms. | 2008 Feb |
|
| Iclaprim, a diaminopyrimidine dihydrofolate reductase inhibitor for the potential treatment of antibiotic-resistant staphylococcal infections. | 2008 Feb |
|
| Registered and investigational drugs for the treatment of methicillin-resistant Staphylococcus aureus infection. | 2008 Jan |
|
| Gateways to clinical trials. | 2008 Jun |
|
| Evidence based approach to the treatment of community-associated methicillin-resistant Staphylococcus aureus. | 2009 |
|
| The determinants of the antibiotic resistance process. | 2009 |
|
| New antimicrobial molecules and new antibiotic strategies. | 2009 Apr |
|
| New antimicrobial agents for methicillin-resistant Staphylococcus aureus. | 2009 Dec |
|
| Future treatment options for Gram-positive infections--looking ahead. | 2009 Dec |
|
| Activity of iclaprim against clinical isolates of Streptococcus pyogenes and Streptococcus agalactiae. | 2009 Feb |
|
| Regulatory watch: Non-inferiority-trial discussions impact new drug applications. | 2009 Jan |
|
| New antibiotics for antibiotic-resistant bacteria. | 2009 May 28 |
|
| [New antibiotics: small or big advances?]. | 2009 Oct |
|
| New treatments for methicillin-resistant Staphylococcus aureus. | 2009 Oct |
|
| Enantioselective synthesis of iclaprim enantiomers--a versatile approach to 2-substituted chiral chromenes. | 2010 Jun 4 |
|
| [Update on antimicrobial chemotherapy]. | 2010 Mar |
|
| Mechanisms of resistance to antimicrobial drugs in pathogenic Gram-positive cocci. | 2010 Sep |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:11:27 GMT 2023
by
admin
on
Sat Dec 16 11:11:27 GMT 2023
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| Record UNII |
7P9VLC9Y9D
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| Record Status |
Validated (UNII)
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| Record Version |
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44141864
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1208116-66-8
Created by
admin on Sat Dec 16 11:11:27 GMT 2023 , Edited by admin on Sat Dec 16 11:11:27 GMT 2023
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7P9VLC9Y9D
Created by
admin on Sat Dec 16 11:11:27 GMT 2023 , Edited by admin on Sat Dec 16 11:11:27 GMT 2023
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ENANTIOMER -> ENANTIOMER |
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RACEMATE -> ENANTIOMER |
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