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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H22O6
Molecular Weight 334.3637
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COMBRETASTATIN

SMILES

COC1=CC=C(C[C@@H](O)C2=CC(OC)=C(OC)C(OC)=C2)C=C1O

InChI

InChIKey=LGZKGOGODCLQHG-CYBMUJFWSA-N
InChI=1S/C18H22O6/c1-21-15-6-5-11(8-14(15)20)7-13(19)12-9-16(22-2)18(24-4)17(10-12)23-3/h5-6,8-10,13,19-20H,7H2,1-4H3/t13-/m1/s1

HIDE SMILES / InChI

Molecular Formula C18H22O6
Molecular Weight 334.3637
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Combretastatin is a phenol derivative isolated from the bark of Combretum caffrum, commonly known as South African Bush Willow. Combretastatin is an effective antimitotic agent, and like colchicine, inhibited tubulin polymerization and stimulated tubulin-dependent GTP hydrolysis.

Approval Year

Substance Class Chemical
Record UNII
7O62J06F18
Record Status Validated (UNII)
Record Version