FANFT

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H5N3O4S
Molecular Weight	239.208
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)C1=CC=C(O1)C2=CSC(NC=O)=N2

InChI

InChIKey=ZQBWQLJJMGJREB-UHFFFAOYSA-N

InChI=1S/C8H5N3O4S/c12-4-9-8-10-5(3-16-8)6-1-2-7(15-6)11(13)14/h1-4H,(H,9,10,12)

HIDE SMILES / InChI

Molecular Formula	C8H5N3O4S
Molecular Weight	239.208
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Experimental bladder tumor induction, propagation, and therapy.	1976 Jul	941358
Uridine 5'-diphosphate galactose: glycoprotein galactosyl transferase activity in exfoliated bladder epithelial cells in rats fed N-(4-(5-nitro-2-furyl)-2-thiazolyl) formamide.	1977	99227
A long-term study of reversible and progressive urinary bladder cancer lesions in rats fed N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.	1977 Aug	872108
Bacillus Calmette-Guérin and dinitrochlorobenzene immunotherapy of chemically induced bladder tumors.	1977 Mar	844999
Reverse transcriptase inhibitors and chemically induced bladder tumors in mice.	1977 Mar	66219
The pathogenesis of bladder cancer.	1977 Nov	920778
Immunogenicity of N-[-4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced bladder cancer.	1978 Dec	748783
Topography and numerical densities of intramembrane particles in chemical carcinogen-induced urinary bladder carcinomas in Fischer rats.	1978 Dec	739760
Desmosome ultrastructure and biological behavior of chemical carcinogen-induced urinary bladder carcinomas.	1978 Oct	688217
[Chemically induced transplantable carcinomas of the urinary bladder in dogs (author's transl)].	1980	7423679
[Epithelial bladder tumor induction in rats with N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide].	1980	7368659
Galactosyl transferase activity in rat bladder transitional cell carcinoma lines and in exfoliated cells in urine during carcinogenesis and reversible hyperplasia.	1980	6778604
Development of an in vitro and in vivo epithelial tumor model for the study of invasion.	1980 Dec	7438091
Effects of urine and continued exposure to carcinogen on progression of early neoplastic urinary bladder lesions.	1980 Dec	7438086
Morphological effects of mitomycin C administered intravesically to normal mice and mice with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induce bladder neoplasms.	1980 Feb	7356509
Immunization by irradiated whole cells or cell extracts against an experimental bladder tumor.	1980 Jan	7351363
Induction of a transplantable urinary bladder carcinoma in dogs.	1980 Jul	7410009
Neovascularization in rats during urinary bladder carcinogenesis induced by N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide.	1980 Jul	6930511
Early induction of mouse urinary bladder ornithine decarboxylase activity by rodent vesical carcinogens.	1980 Jun	7371022
Synthetic retinamides: effect on urinary bladder carcinogenesis by FANFT in Fischer rats.	1981	7273332
Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.	1981 Aug	7248968
The effect of single dose N-methyl-N-nitrosourea on bladder carcinogenesis by N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide in rats.	1981 May	7228579
13-cis-retinoic acid: effect on urinary bladder carcinogenesis by N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide in Fischer rats.	1981 May	6946855
Potentiation of dimethylhydrazine bowel carcinogenesis in rats.	1981 May 1	7226115
Comparison between a purified and standard diet on FANFT-induced murine bladder cancer.	1981 Nov	7314340
Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens.	1981 Nov	7306987
Aspirin inhibition of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced lesions of the urinary bladder correlated with inhibition of metabolism by bladder prostaglandin endoperoxide synthetase.	1981 Sep	6790163
Expression of the cellular immune response during tumor development in an animal model of bladder cancer.	1982 Dec	7154212
Single and sequential combination intravesical chemotherapy of murine bladder cancer.	1982 Feb	6800090
Growth characteristics of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced mouse bladder tumor lines in a human tumor stem cell assay.	1982 Jan 15	7032684
In vitro characterization of four N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) induced mouse bladder tumors.	1982 Jun	7087044
Time- and concentration-dependent inhibition of the clonogenic growth of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor cell lines by cis-diamminedichloroplatinum(II).	1982 Mar	7199379
Rat bladder isograft model for focal carcinoma.	1982 Sep	7120581
Co-carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for the urinary bladder.	1983	6821891
Keyhole-limpet haemocyanin (KLH) immunotherapy of murine transitional cell carcinoma.	1983	6659223
Long term dose response study of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced urinary bladder carcinogenesis.	1983 Apr	6850560
The use of a tumor colony assay in predicting chemotherapeutic drug response in murine bladder cancer.	1983 Aug 15	6861100
Effect of phenobarbital on the carcinogenesis of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in rats.	1983 Jul	6883313
Cellular changes in rat urinary bladder carcinomas induced by FANFT: a quantitative electron microscopic analysis.	1983 Mar	6834570
Multistage carcinogenesis in the urinary bladder.	1983 Mar	6832093
Metastatic characteristics of four FANFT-induced murine bladder tumors.	1983 Nov	6649210
The influence of phenacetin or mechanical perforation on the development of renal pelvic and urinary bladder tumors in FANFT-induced urinary tract carcinogenesis.	1983 Sep	6613585
A murine model for bladder cancer.	1984	6541340
Enhancement by phenothiazine and 2,5-di-O-acetyl-D-glucosaccharo-(1,4)(6,3)-dilactone of bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide in rats.	1984 Aug	6548659
Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat.	1984 Jan	6692345
Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced bladder carcinogenesis and enhancement of forestomach carcinogenesis.	1984 Jan	6690086
The Noble rat bladder cancer model. FANFT-induced tumors.	1984 Mar 1	6692301
Liver NADPH-dependent oxidation of the 5-nitrofurans, FANFT and ANFT, by guinea pig and rat.	1993 Feb	8498082
Effect of indomethacin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced urinary tract carcinogenesis.	1995 Jul	7614682
Tumor versus vascular photodamage in a rat tumor model.	1998 Aug 21	9819896

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:12:38 UTC 2023` Edited by `admin` on `Fri Dec 15 17:12:38 UTC 2023`
Record UNII	7N99PZG62O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FANFT

Common Name

English

NSC-155010

Code

English

N-(4-(5-NITRO-2-FURYL)-2-THIAZOLYL)FORMAMIDE

Systematic Name

English

N-(4-(5-NITRO-2-FURANYL)-2-THIAZOLYL)FORMAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

32486