Technetium Tc 99m Gluconate is a radiopharmaceutical agent that has been used for the diagnosis of kidney disease. Although Technetium Tc 99m Gluconate is of a hydrophilic character, it shows high plasma protein binding (50–70%). Therefore, both glomerular filtration and tubular excretion by the kidneys occur with slow pharmacokinetics, and only 70% of the injected activity is washed out after one day. This is the reason why Technetium Tc 99m Gluconate is no longer used for renal studies. Owing to its low stability, Technetium Tc 99m Gluconate is used (i) for red blood cell labeling and (ii) as a ligand exchange partner for labeling other molecules