U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 21:25:32 GMT 2025
Edited
by admin
on Wed Apr 02 21:25:32 GMT 2025
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Retroviridae
Organism Genus Lentivirus
Organism Species human immunodeficiency virus 1
Infraspecific Type RECOMBINANT VECTOR
Infraspecific Name SIN/LV-VHH6-linker-VHH6-KDEL
Part whole
Record UNII
7MX7Z5GUU5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Osencabtagene autoleucel lentiviral vector with CD7-blocking gene
Preferred Name English
Code System Code Type Description
FDA UNII
7MX7Z5GUU5
Created by admin on Wed Apr 02 21:25:32 GMT 2025 , Edited by admin on Wed Apr 02 21:25:32 GMT 2025
PRIMARY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
GENE_EXPRESSION VECTOR Osencabtagene autoleucel transgene insert encoding bivalent anti-CD7 nano-antibody sequence endoplasmic reticulum retention sequence (CD7-blocking gene) JUE5XG7E5Z