U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 21:25:32 GMT 2025
Edited
by admin
on Wed Apr 02 21:25:32 GMT 2025
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Retroviridae
Organism Genus Lentivirus
Organism Species human immunodeficiency virus 1
Infraspecific Type RECOMBINANT VECTOR
Infraspecific Name SIN/LV-VHH6-linker-VHH6-KDEL
Part whole
Record UNII
7MX7Z5GUU5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Osencabtagene autoleucel lentiviral vector with CD7-blocking gene
Preferred Name English
Code System Code Type Description
FDA UNII
7MX7Z5GUU5
Created by admin on Wed Apr 02 21:25:32 GMT 2025 , Edited by admin on Wed Apr 02 21:25:32 GMT 2025
PRIMARY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
GENE_EXPRESSION VECTOR Osencabtagene autoleucel transgene insert encoding bivalent anti-CD7 nano-antibody sequence endoplasmic reticulum retention sequence (CD7-blocking gene) JUE5XG7E5Z