SODIUM ARSPHENAMINE

US Previously Marketed

First marketed in 1910

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H10As2N2O2.2Na
Molecular Weight	410.0427
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].NC1=CC(=CC=C1[O-])\[As]=[As]\C2=CC=C([O-])C(N)=C2

InChI

InChIKey=AHXJGEBYGJABES-UHFFFAOYSA-L

InChI=1S/C12H12As2N2O2.2Na/c15-9-5-7(1-3-11(9)17)13-14-8-2-4-12(18)10(16)6-8;;/h1-6,17-18H,15-16H2;;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C12H10As2N2O2
Molecular Weight	364.0632
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19679737

Arsphenamine (brand name Salvarsan), a drug contains arsenic, was used to treat syphilis, but then it was substituted by the more active and less toxic agent.

Originator

Approval Year

PubMed

Title	Date	PubMed
The introduction of 'chemotherapy' using arsphenamine - the first magic bullet.	2009 Aug	19679737
History of antibiotics. From salvarsan to cephalosporins.	2012 Apr	22439833
[Evolution of treatment of syphilis through history].	2018 Dec	30427145

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:54:43 GMT 2023` Edited by `admin` on `Fri Dec 15 18:54:43 GMT 2023`
Record UNII	7M91W8X059
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM ARSPHENAMINE

Common Name

English

4,4'-(1,2-DIARSENEDIYL)BIS(2-AMINOPHENOL) DISODIUM SALT SALT

Common Name

English

ARSPHENAMINE SODIUM

Common Name

English

Arsphenamine sodium [WHO-DD]

Common Name

English

SODIUM ARSPHENAMINE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

7M91W8X059