SODIUM ARSPHENAMINE

US Previously Marketed

First marketed in 1910

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H10As2N2O2.2Na
Molecular Weight	410.0427
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].NC1=C([O-])C=CC(=C1)\[As]=[As]\C2=CC(N)=C([O-])C=C2

InChI

InChIKey=AHXJGEBYGJABES-UHFFFAOYSA-L

InChI=1S/C12H12As2N2O2.2Na/c15-9-5-7(1-3-11(9)17)13-14-8-2-4-12(18)10(16)6-8;;/h1-6,17-18H,15-16H2;;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C12H10As2N2O2
Molecular Weight	364.0632
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19679737

Arsphenamine (brand name Salvarsan), a drug contains arsenic, was used to treat syphilis, but then it was substituted by the more active and less toxic agent.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Evolution of treatment of syphilis through history].	2018-12	30427145
History of antibiotics. From salvarsan to cephalosporins.	2012-04	22439833
The introduction of 'chemotherapy' using arsphenamine - the first magic bullet.	2009-08	19679737

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:25:55 GMT 2025` Edited by `admin` on `Mon Mar 31 19:25:55 GMT 2025`
Record UNII	7M91W8X059
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ARSPHENAMINE SODIUM

Preferred Name

English

SODIUM ARSPHENAMINE

Common Name

English

4,4'-(1,2-DIARSENEDIYL)BIS(2-AMINOPHENOL) DISODIUM SALT SALT

Common Name

English

Arsphenamine sodium [WHO-DD]

Common Name

English

SODIUM ARSPHENAMINE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

7M91W8X059