COBALTOUS BROMIDE

US Approved Allergenic Extract (1994)

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Br.Co
Molecular Weight	218.741
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Co++].[Br-].[Br-]

InChI

InChIKey=BZRRQSJJPUGBAA-UHFFFAOYSA-L

InChI=1S/2BrH.Co/h2*1H;/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Co
Molecular Weight	58.9332
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Hypoxia-inducible factor 1-alpha inhibitor 22 Target ID: Q9NWT6 Gene ID: 55662.0 Gene Symbol: HIF1AN Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15941769	Inhibitor 8297		1.0 µM [Ki]

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Anemia 68 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18120180 https://www.ncbi.nlm.nih.gov/pubmed/940922	Primary	Withdrawn	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.	1990 Aug	2227161
Cobalt and antimony: genotoxicity and carcinogenicity.	2003 Dec 10	14643417

Patents

Sample Use Guides

In Vivo Use Guide

For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.

Route of Administration: Oral

In Vitro Use Guide

HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:40:27 UTC 2023` Edited by `admin` on `Fri Dec 15 19:40:27 UTC 2023`
Record UNII	7M7RX75BAL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COBALTOUS BROMIDE

Common Name

English

COBALT DIBROMIDE

Systematic Name

English

COBALTOUS BROMIDE [MI]

Common Name

English

COBALT DIBROMIDE [HSDB]

Common Name

English

COBALT(II) BROMIDE

Systematic Name

English

COBALT BROMIDE (COBR2)

Common Name

English

Code System Code Type Description

FDA UNII

7M7RX75BAL