NISTERIME ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H35ClN2O5
Molecular Weight	503.03
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](OC(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])CC[C@@]4([H])C\C(=N\OC5=CC=C(C=C5)[N+]([O-])=O)[C@H](Cl)C[C@]34C

InChI

InChIKey=NNFGKFKPLQYECP-BYXNGVTISA-N

InChI=1S/C27H35ClN2O5/c1-16(31)34-25-11-10-21-20-9-4-17-14-24(29-35-19-7-5-18(6-8-19)30(32)33)23(28)15-27(17,3)22(20)12-13-26(21,25)2/h5-8,17,20-23,25H,4,9-15H2,1-3H3/b29-24-/t17-,20-,21-,22-,23+,25-,26-,27-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H35ClN2O5
Molecular Weight	503.03
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ru/books?id=iknTBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false
Curator's Comment: Description was created based on several sources, including https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA876#v=onepage&q&f=false

Nisterime is a dihydrotestosterone derivative. Nisterime acetate (ORF-9326) was shown to inhibit implantation in several species. It is also interrupts the postimplantation stage of gestation.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Androgen Receptor 167 Target ID: CHEMBL1871 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D05174	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pregnancy 65 Sources: Glasser, S.R. & Bullock, D.W. (2012) Cellular and Molecular Aspects of Implantation, page 479, retrieved from: https://books.google.ru/books?id=iknTBwAAQBAJ	Preventing		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Disposition of ORF 9326, a novel contragestational steroid, in animals.	1978 Sep	102053

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:58:28 GMT 2023` Edited by `admin` on `Fri Dec 15 14:58:28 GMT 2023`
Record UNII	7M1ALD652F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NISTERIME ACETATE

Official Name

English

ANDROSTAN-3-ONE, 17-(ACETYLOXY)-2-CHLORO-, 3-(O-(4-NITROPHENYL)OXIME), (2.ALPHA.,5.ALPHA.,17.BETA.)-

Common Name

English

NISTERIME ACETATE [USAN]

Common Name

English

ORF 9326

Code

English

ORF-9326

Code

English

2.ALPHA.-CHLORO-17.BETA.-HYDROXY-5.ALPHA.-ANDROSTAN-3-ONE O-(P-NITROPHENYL)OXIME ACETATE (ESTER)

Common Name

English

Code System Code Type Description

WIKIPEDIA

Nisterime acetate