4',7,8-TRIHYDROXYISOFLAVONE

OC1=CC=C(C=C1)C2=COC3=C(O)C(O)=CC=C3C2=O

InChIKey=BMZFZTMWBCFKSS-UHFFFAOYSA-N

InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Protein kinase C iota type 1 Target ID: P41743 Gene ID: 5584.0 Gene Symbol: PRKCI Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28453925	Inhibitor 8297
endothelial cell-cell adhesion 1 Target ID: GO:0071603 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28946319	Inhibitor 8297
Hepatitis C virus NS3 protease/helicase 5 Target ID: CHEMBL4893 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25586033	Inhibitor 8297

PubMed

Title	Date	PubMed
A major daidzin metabolite 7,8,4'-trihydroxyisoflavone found in the plasma of soybean extract-fed rats attenuates monocyte-endothelial cell adhesion.	2018 Feb 1	28946319
PKCι is a target of 7,8,4'-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression.	2018 May	28453925

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:41:00 GMT 2023` Edited by `admin` on `Sat Dec 16 15:41:00 GMT 2023`
Record UNII	7KW44TB2DE
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

4',7,8-TRIHYDROXYISOFLAVONE

Common Name

English

3-(4-HYDROXYPHENYL)-7,8-BIS(OXIDANYL)CHROMEN-4-ONE

Systematic Name

English

NSC-678112

Code

English

7,8-DIHYDROXY-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE

Systematic Name

English

4H-1-BENZOPYRAN-4-ONE, 7,8-DIHYDROXY-3-(4-HYDROXYPHENYL)-

Systematic Name

English

7,8-DIHYDROXY-3-(4-HYDROXYPHENYL)CHROMEN-4-ONE

Systematic Name

English

Code System Code Type Description

PUBCHEM

5466139