U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H13N5O
Molecular Weight 219.2431
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ZEATIN

SMILES

C\C(CO)=C/CNC1=NC=NC2=C1N=CN2

InChI

InChIKey=UZKQTCBAMSWPJD-FARCUNLSSA-N
InChI=1S/C10H13N5O/c1-7(4-16)2-3-11-9-8-10(13-5-12-8)15-6-14-9/h2,5-6,16H,3-4H2,1H3,(H2,11,12,13,14,15)/b7-2+

HIDE SMILES / InChI

Molecular Formula C10H13N5O
Molecular Weight 219.2431
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Zeatin is a cytokinin plant growth factor, which has gerontomodulatory, youth preserving and anti-aging effects on serially passaged human adult skin fibroblasts undergoing aging in vitro.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
2001 Jul
Zeatin prevents amyloid beta-induced neurotoxicity and scopolamine-induced cognitive deficits.
2009 Apr
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
Zeatin has gerontomodulatory, youth preserving and anti-aging effects on serially passaged human adult skin fibroblasts undergoing aging in vitro. There were no immediate negative or toxic effects in terms of cell attachment, cell proliferation, cell survival, cytoskeletal organization, and cellular growth by treatment with zeatin concentrations between 1 and 200 microM. During long-term treatment, cells could be maintained throughout their replicative lifespan in the presence of 40, 80, and 200 microM zeatin, but the optimal concentration of zeatin's anti-aging and youth-preserving effects was found to be 80 microM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:01:55 GMT 2023
Edited
by admin
on Fri Dec 15 19:01:55 GMT 2023
Record UNII
7I6OOJ9GR6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZEATIN
HSDB   INCI   MI  
INCI  
Official Name English
ZEATIN [HSDB]
Common Name English
(E)-2-METHYL-4-(9H-PURIN-6-YLAMINO)BUT-2-EN-1-OL
Systematic Name English
ZEATIN [MI]
Common Name English
(2E)-2-METHYL-4-(1H-PURIN-6-YLAMINO)-2-BUTEN-1-OL
Systematic Name English
ZEATIN [INCI]
Common Name English
(E)-ZEATIN
Common Name English
TRANS-ZEATIN
Common Name English
Code System Code Type Description
WIKIPEDIA
ZEATIN
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
DRUG BANK
DB11337
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
FDA UNII
7I6OOJ9GR6
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
MERCK INDEX
m11585
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY Merck Index
PUBCHEM
449093
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
DAILYMED
7I6OOJ9GR6
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
CHEBI
15333
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
RXCUI
1440227
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID9040631
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
HSDB
7689
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
CHEBI
16522
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
CAS
1637-39-4
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
ALANWOOD
zeatin
Created by admin on Fri Dec 15 19:01:55 GMT 2023 , Edited by admin on Fri Dec 15 19:01:55 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY