Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C6H11NO3S |
Molecular Weight | 177.221 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](C[S@@+]([O-])CC=C)C(O)=O
InChI
InChIKey=XUHLIQGRKRUKPH-DYEAUMGKSA-N
InChI=1S/C6H11NO3S/c1-2-3-11(10)4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-,11-/m0/s1
Molecular Formula | C6H11NO3S |
Molecular Weight | 177.221 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Alliin (S-allyl-l-cysteine sulfoxides, SACSO) is the major component of aged garlic extract, bearing broad-spectrum natural antioxidant properties. It was revealed, that alliin had an inhibitory effect in osteoclasteogenesis with a dose-dependent manner via blocking the c-Fos-NFATc1 signaling pathway and it could be a potential therapeutic agent for the treatment of osteoporosis. In addition, alliin ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation.
Approval Year
PubMed
Title | Date | PubMed |
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Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. | 1999 Sep |
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Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox1. | 2016 Sep 20 |
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Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation. | 2017 Sep |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28371322
in colitis mice: dextran sulfate sodium (DSS)-induced and/or alliin (500 mg/kg) groups
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10501628
Curator's Comment: The in vitro effect of alliin, on the mitogen induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production was examined. It was concluded that alliin in vitro exerts an immunomodulatory effect on certain functions of the peripheral blood cells. The results showed an increase in pokeweed mitogen (PWM) induced cell proliferation, IL-1beta and TNF-alpha production, as well as in the engulfing capacity of both percentage of phagocyting cells and number of latex particles phagocytized by each individual cell. The Con-A induced cell proliferation and IL-6 production decreased following incubation with alliin, whereas PHA-induced cell proliferation, IL-2 and superoxide anion generation remained unchanged.
Unknown
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 07:10:55 GMT 2023
by
admin
on
Sat Dec 16 07:10:55 GMT 2023
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Record UNII |
7I4L2D0E9G
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Record Status |
Validated (UNII)
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Record Version |
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2894 (Number of products:19)
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300000025703
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2596
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556-27-4
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132987
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1012950
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m1524
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7I4L2D0E9G
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9576089
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ALLIIN
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209-118-9
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DTXSID801020639
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PARENT -> CONSTITUENT ALWAYS PRESENT |
USP
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