PICONOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H7NO
Molecular Weight	109.1259
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCC1=NC=CC=C1

InChI

InChIKey=SHNUBALDGXWUJI-UHFFFAOYSA-N

InChI=1S/C6H7NO/c8-5-6-3-1-2-4-7-6/h1-4,8H,5H2

HIDE SMILES / InChI

Molecular Formula	C6H7NO
Molecular Weight	109.1259
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/448683
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/28440382

Piconol (2-Pyridinemethanol) is a pyridylalcohol devivative with hypoglycemic activity.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes mellitus 93 Sources: https://www.ncbi.nlm.nih.gov/pubmed/448683	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Mn8 and Mn16 clusters from the use of 2-(hydroxymethyl)pyridine, and comparison with the products from bulkier chelates: a new high nuclearity single-molecule magnet.	2010-11-15	20961147
[(2-Pyrid-yl)methanol-κN,O]bis-(thio-cyanato-κN)manganese(II).	2010-09-04	21587362
Bis(ferrocene-carboxyl-ato-κO)bis-(2-pyridyl-methanol-κN,O)cobalt(II).	2010-06-05	21587689
A tetra-nuclear cobalt(III) cluster with 2-(hydroxy-meth-yl)pyridine ligands.	2010-04-30	21579067
A linear tetranuclear single-molelcule magnet of Mn(II)(2)Mn(III)(2) with the anion of 2-(Hydroxymethyl)pyridine.	2010-04-19	20337485
A divergent strategy for attaching polypyridyl ligands to peptides.	2010-02-05	20047343
Mn(7) and Mn(12) clusters from use of 2-(pyridine-2-yl)propan-2-ol: a new half-integer single-molecule magnet.	2010-01-04	19961209
The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine.	2010-01	19853978
Synthesis and Structural Characterization of a Metal Cluster and a Coordination Polymer Based on the [Mn(6)(mu(4)-O)(2)] Unit.	2010	20634987
A rapid and sensitive method for the simultaneous analysis of aliphatic and polar molecules containing free carboxyl groups in plant extracts by LC-MS/MS.	2009-11-25	19939243
Mn4, Mn6, and Mn11 clusters from the use of bulky diphenyl(pyridine-2-yl)methanol.	2009-10-05	19728691
Magnetic quantum tunneling: key insights from multi-dimensional high-field EPR.	2009-08-21	19639148
Coordination assemblies of [Mn4] single-molecule magnets linked by photochromic ligands: photochemical control of the magnetic properties.	2009-07-22	19601686
Azide groups in higher oxidation state manganese cluster chemistry: from structural aesthetics to single-molecule magnets.	2009-04-20	19364123
Stepwise modification of titanium alkoxy chloride compounds by pyridine carbinol.	2008-11-17	18937448
2-(Hydroxy-meth-yl)pyridinium chloride.	2008-10-31	21581087
Influence of (hydroxymethyl)pyridine and pyridine-carboxylic acids, in trans-position to the isopropylamine and amine ligands, on the cytotoxicity of platinum complexes.	2008-10	18972499
Dichlorido(methanol-κO)[2-(2-pyridyl-meth-oxy)-1,10-phenanthroline-κN,N',N'']manganese(II).	2008-06-25	21202809
A porphyrin derivative containing 2-(oxymethyl)pyridine units showing unexpected ratiometric fluorescent recognition of Zn2+ with high selectivity.	2008-06-02	18482606
High-spin Mn4 and Mn10 molecules: large spin changes with structure in mixed-valence MnII4MnIII6 clusters with azide and alkoxide-based ligands.	2008-06-02	18454518
Picolinoxy group, a new leaving group for anti SN2' selective allylic substitution with aryl anions based on Grignard reagents.	2008-05-01	18396885
Strongly correlated electrons in the [Ni(hmp)(ROH)X]4 single molecule magnet: a DFT+U study.	2008-04-25	18518243
Heterometallic integer-spin analogues of S = 9/2 Mn4 cubane single-molecule magnets.	2008-04-21	18327894
Synthesis of nickel complexes with bidentate N,O-type ligands and application in the catalytic oligomerization of ethylene.	2008-03-28	18335140
Disorder and intermolecular interactions in a family of tetranuclear Ni(II) complexes probed by high-frequency electron paramagnetic resonance.	2008-03-17	18284196
Lower-rim substituted calixarenes and their applications.	2007	17611612
Supramolecular allosteric cofacial porphyrin complexes.	2006-12-20	17165783
Chelation-assisted transformation: synthesis of 1,4-dicarboxylate esters by the Rh-catalyzed carbonylation of internal alkynes with pyridin-2-ylmethanol.	2006-06-08	16737303
Two-dimensional networks based on Mn4 complex linked by dicyanamide anion: from single-molecule magnet to classical magnet behavior.	2006-03-22	16536552
Fast magnetization tunneling in tetranickel(II) single-molecule magnets.	2006-01-23	16411688
Synthesis, structures, and magnetic properties of heteronuclear Cu(II)-Ln(III) (Ln = La, Gd, or Tb) complexes.	2005-11-14	16270967
Quantum tunneling and quantum phase interference in a [Mn(II)2Mn(III)2] single-molecule magnet.	2005-08-17	16089460
Single-molecule magnets: high-field electron paramagnetic resonance evaluation of the single-ion zero-field interaction in a Zn(II)3Ni(II) complex.	2005-05-30	15907107
Benzofuran- and furan-2-yl-(phenyl)-3-pyridylmethanols: synthesis and inhibition of P450 aromatase.	2005-04	15968818
Phosphazene-based ionic liquids: synthesis, temperature-dependent viscosity, and effect as additives in water lubrication of silicon nitride ceramics.	2004-08-23	15310229
Discovery of the first non-peptide full agonists for the human bradykinin B(2) receptor incorporating 4-(2-picolyloxy)quinoline and 1-(2-picolyl)benzimidazole frameworks.	2004-05-20	15139763
3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.	2004-03-25	15027873
ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.	2004-03	15016363
Pyridinium-carbaldehyde: active Maillard reaction product from the reaction of hexoses with lysine residues.	2004-02-25	15013409
Simple synthesis of beta-D-glycopyranosides using beta-glycosidase from almonds.	2004-02	14758017
Chelation-assisted hydroesterification of alkenes catalyzed by rhodium complex.	2003-11-13	14601992
Heptanuclear and decanuclear manganese complexes with the anion of 2-hydroxymethylpyridine.	2003-11-03	14577774
2-(hydroxymethyl)pyridinium dihydrogenphosphate.	2003-07	12855862
Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors.	2003-06-02	12749899
Bis(2-pyridylmethanol)bis(saccharinato)zinc(II) and -cadmium(II) at 120 K: three-dimensional structures containing both N-and O-coordinated ambidentate saccharinate ligands.	2002-08	12154282
Single-molecule magnets: a new family of Mn(12) clusters of formula [Mn(12)O(8)X(4)(O(2)CPh)(8)L(6)].	2002-04-10	11929262
Synthesis, structure, and magnetic properties of tetranuclear cubane-like and chain-like iron(II) complexes based on the N(4)O pentadentate dinucleating ligand 1,5-bis[(2-pyridylmethyl)amino]pentan-3-ol.	2002-03-25	11896717
Mixed-valence tetranuclear manganese single-molecule magnets.	2001-08-27	11511205
Adsorption of hydroxy pyridines and quinolines at the metal oxide-water interface: role of tautomeric equilibrium.	2001-05-15	11393981
In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).	2001-04-23	11327589

Patents

Sample Use Guides

In Vivo Use Guide

Rats were treated with Piconol at 150 mg/kg, po

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:13:01 GMT 2025` Edited by `admin` on `Mon Mar 31 18:13:01 GMT 2025`
Record UNII	7HQ8UT1TPS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PICONOL

Official Name

English

2-PYRIDINEMETHANOL

Preferred Name

English

NSC-760363

Code

English

piconol [INN]

Common Name

English

Code System Code Type Description

CAS

586-98-1