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Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. Synthetic human secretin displays equivalent biological activity and properties as naturally occurring secretin. Acetate salt of synthetic secretin was marketed under the name ChiRhoStim. ChiRhoStim is indicated for the stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction, for the gastrin secretion to aid in the diagnosis of gastrinoma. ChiRhoStim is also used for the pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic, retrograde cholangiopancreatography (ERCP). When secretin binds to secretin receptors on pancreatic duct cells it opens cystic fibrosis transmembrane conductance regulator (CFTR) channels, leading to secretion of bicarbonate-rich-pancreatic fluid.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P47872
Gene ID: 6344.0
Gene Symbol: SCTR
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
ChiRhoStim

Approved Use

ChiRhoStim® is a secretin class hormone indicated for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of exocrine pancreas dysfunction; gastrin secretion to aid in the diagnosis of gastrinoma; pancreatic secretions to facilitate the identification of the ampulla of Vater and the accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).

Launch Date

2004
PubMed

PubMed

TitleDatePubMed
Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia.
2005 Oct
Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor.
2012 May

Sample Use Guides

Stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of exocrine pancreas dysfunction: 0.2 mcg/kg by intravenous injection over 1 minute Stimulation of gastrin secretion to aid in diagnosis of gastrinoma:0.4 mcg/kg by intravenous injection over 1 minute Stimulation of pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography ERCP): 0.2 mcg/kg by intravenous injection over 1 minute
Route of Administration: Intravenous
Substance Class Protein
Created
by admin
on Sat Dec 16 05:45:34 GMT 2023
Edited
by admin
on Sat Dec 16 05:45:34 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
7HP60U6HMM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SECRETIN HUMAN PENTAHYDROCHLORIDE
Common Name English
HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-GLU-GLY-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2 PENTAHYDROCHLORIDE
Common Name English
SECRETIN (PIG), 15-L-GLUTAMIC ACID-16-GLYCINE-, PENTAHYDROCHLORIDE
Common Name English
SECRETIN PENTAHYDROCHLORIDE
Common Name English
SECRELUX
Brand Name English
Code System Code Type Description
PUBCHEM
118984443
Created by admin on Sat Dec 16 05:45:34 GMT 2023 , Edited by admin on Sat Dec 16 05:45:34 GMT 2023
PRIMARY
FDA UNII
7HP60U6HMM
Created by admin on Sat Dec 16 05:45:34 GMT 2023 , Edited by admin on Sat Dec 16 05:45:34 GMT 2023
PRIMARY
CAS
108072-62-4
Created by admin on Sat Dec 16 05:45:34 GMT 2023 , Edited by admin on Sat Dec 16 05:45:34 GMT 2023
PRIMARY
SMS_ID
100000084948
Created by admin on Sat Dec 16 05:45:34 GMT 2023 , Edited by admin on Sat Dec 16 05:45:34 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:SEQUENCE(CALCULATION) CHEMICAL
Molecular Formula CHEMICAL