MEBEZONIUM IODIDE

Possibly Marketed Outside US

Details

Stereochemistry	MIXED
Molecular Formula	C19H40N2.2I
Molecular Weight	550.3432
Optical Activity	NONE
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[I-].[I-].C[N+](C)(C)C1CCC(CC2CCC(CC2)[N+](C)(C)C)CC1

InChI

InChIKey=CWPAAKNARYMZLM-UHFFFAOYSA-L

InChI=1S/C19H40N2.2HI/c1-20(2,3)18-11-7-16(8-12-18)15-17-9-13-19(14-10-17)21(4,5)6;;/h16-19H,7-15H2,1-6H3;2*1H/q+2;;/p-2

HIDE SMILES / InChI

Molecular Formula	C19H40N2
Molecular Weight	296.5343
Charge	2
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HI
Molecular Weight	127.91241
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://animalstudiesrepository.org/cgi/viewcontent.cgi?article=1001&context=acwp_vsm

Mebezonium is a component of T-61/Tanax (a combination of embutramide, mebezonium iodide, tetracaine hydrochloride), a product which is indicated for euthanasia in animals. The drug was withdrawn from the market by the manufacturer's decision.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Euthanasia 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27404634	Primary		Approved 8583	T-61 EUTHANASIA SOLUTION Approved Use Euthanasia in domestic animals.

Doses

Dose	Population	Adverse events
37.5 mg/kg single, oral Accidental dose Dose: 37.5 mg/kg Route: oral Route: single Dose: 37.5 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/8462375/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/8462375/	Other AEs: Hepatic failure... Other AEs: Hepatic failure (grade 3) Sources: https://pubmed.ncbi.nlm.nih.gov/8462375/

AEs

AE	Significance	Dose	Population
Hepatic failure	grade 3	37.5 mg/kg single, oral Accidental dose Dose: 37.5 mg/kg Route: oral Route: single Dose: 37.5 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/8462375/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/8462375/

PubMed

Title	Date	PubMed
Dimethylformamide metabolism following self-harm using a veterinary euthanasia product.	2010-08	20849330
Different solutions used for submucosal injection influenced early healing of gastric endoscopic mucosal resection in a preclinical study in experimental pigs.	2009-09	19057952
Effects of electromagnetic fields of low frequency and low intensity on rat metabolism.	2008-04-01	18380892
Screening procedure for eight quaternary nitrogen muscle relaxants in blood by high-performance liquid chromatography-electrospray ionization mass spectrometry.	2003-06-05	12726849
Blood investigation in a fatality involving the veterinary drug T-61.	2002-10	12423012

Sample Use Guides

In Vivo Use Guide

Dogs: Intravenous injection: 0.3 ml/kg. Intracardiac injection: Up to 10 kg: 7-10 ml/animal. Over 10 kg: 10 ml first, and as soon as the animal is lying, another dose of 3-10 ml, depending on the size of the animal, intrapulmonary or intracardiac. - Cats: Intravenous injection: 0.3 ml/kg. Intracardiac/intrapulmonary injection: Cats of few days of life old: 1 ml/animal. Cats older than six months: 3 ml/animal. Cats older than six months of age: 5 ml/animal. Cats over 5 kg: 10 ml/animal. - Marten and other fur animals: Injection intracardiac/intrapulmonary 0.5 - 1 ml/animal. - Horses and cattle not intended for animal or human consumption: Recommended dose of 4-6 ml/50 kg, injected intravenously. - Other animals: Such as ornamental birds and small laboratory animals: 0.2 to 2 ml/animal

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:29:44 GMT 2025` Edited by `admin` on `Mon Mar 31 21:29:44 GMT 2025`
Record UNII	7GVF119EM8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(METHYLENEDI-1,4-CYCLOHEXYLENE)BIS(TRIMETHYLAMMONIUM IODIDE)

Preferred Name

English

MEBEZONIUM IODIDE

Official Name

English

MEBENZONIUM IODIDE

Common Name

English

CYCLOHEXANAMINIUM, 4,4'-METHYLENEBIS(N,N,N-TRIMETHYL-, IODIDE (1:2)

Systematic Name

English

mebezonium iodide [INN]

Common Name

English

MEBEZONIUM IODIDE [GREEN BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29696