PROSPIDIUM CHLORIDE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C18H36Cl2N4O2.2Cl
Molecular Weight	482.316
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].[Cl-].OC(CCl)CN1CC[N+]2(CC1)CC[N+]3(CCN(CC(O)CCl)CC3)CC2

InChI

InChIKey=QZJPEEOEZVHUAE-UHFFFAOYSA-L

InChI=1S/C18H36Cl2N4O2.2ClH/c19-13-17(25)15-21-1-5-23(6-2-21)9-11-24(12-10-23)7-3-22(4-8-24)16-18(26)14-20;;/h17-18,25-26H,1-16H2;2*1H/q+2;;/p-2

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H34Cl2N4O2
Molecular Weight	409.394
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6225629 | https://www.ncbi.nlm.nih.gov/pubmed/7315580 | https://www.ncbi.nlm.nih.gov/pubmed/6571330

Prospidium is a diazoniadispiro(5.2.5.2)hexadecane derivative patented by All-Union Scientific-Research Chemical-Pharmaceutical Institute as an antitumor agent that does not inhibit hematopoiesis. In preclinical models, The injection of Prospidium to thyroidectomized and hypophysectomized rats inhibited tumor growth to a greater extent than in intact rats. Larynx and lung cancer, lymphogranulomatosis, leucosis, etc. can be successfully treated with Prospidium at doses of 60-120 mg daily.

Originator

Approval Year

PubMed

Title	Date	PubMed
[A new basic drug prospidin in the treatment of rheumatoid arthritis. III. Comparative analysis of prospidin and cyclophosphamide].	1987	3035735

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:02:41 GMT 2023` Edited by `admin` on `Fri Dec 15 16:02:41 GMT 2023`
Record UNII	7G733H6RES
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROSPIDIUM CHLORIDE

Official Name

English

Prospidium chloride [WHO-DD]

Common Name

English

NSC-166100

Code

English

PROSPIDIUM CHLORIDE [MART.]

Common Name

English

prospidium chloride [INN]

Common Name

English

3,12-BIS(3-CHLORO-2-HYDROXYPROPYL)-3,12-DIAZA-6,9-DIAZONIADISPIRO(5.2.5.2)HEXADECANE DICHLORIDE

Systematic Name

English

3,6,9,12-TETRAAZADISPIRO(5.2.5.2)HEXADECAN-6,9-IUM, 3,12-BIS(3-CHLORO-2-HYDROXYPROPYL)-, CHLORIDE (1:2)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C574