U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 19:53:18 GMT 2025
Edited
by admin
on Wed Apr 02 19:53:18 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1|KAPPA
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
7ER98K4WW9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Immunoglobulin G1, anti-(human/Macaca fascicularis/Mus musculus/Canis familiaris/Rattus norvegicus claudin CLDN18.2) (human-Mus musculus monoclonal RC118-B186314B11S ?1-chain), complex with human-Mus musculus monoclonal RC118-B186314B11S ?-chain, dimer,
Preferred Name English
Ciletatug Vedotin
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ) isoform 2], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker a
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ) isoform 2], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker a
Common Name English
ciletatug vedotin [INN]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C180906
Created by admin on Wed Apr 02 19:53:18 GMT 2025 , Edited by admin on Wed Apr 02 19:53:18 GMT 2025
PRIMARY
FDA UNII
7ER98K4WW9
Created by admin on Wed Apr 02 19:53:18 GMT 2025 , Edited by admin on Wed Apr 02 19:53:18 GMT 2025
PRIMARY
INN
13111
Created by admin on Wed Apr 02 19:53:18 GMT 2025 , Edited by admin on Wed Apr 02 19:53:18 GMT 2025
PRIMARY
CAS
2897624-59-6
Created by admin on Wed Apr 02 19:53:18 GMT 2025 , Edited by admin on Wed Apr 02 19:53:18 GMT 2025
PRIMARY
SMS_ID
300000056823
Created by admin on Wed Apr 02 19:53:18 GMT 2025 , Edited by admin on Wed Apr 02 19:53:18 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_146 2_202
2_222 4_220
2_263 2_323
1_146 1_202
2_369 2_427
3_23 3_94
3_140 3_200
4_23 4_94
4_140 4_200
1_222 3_220
1_228 2_228
1_231 2_231
1_263 1_323
1_369 1_427
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_299
N 2_299
Related Record Type Details
TARGET->LIGAND
TOXIN -> CONJUGATE
PARENT -> CONJUGATE
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Q PIDOLIC ACID SZB83O1W42
AMINO_ACID_SUBSTITUTION C-TERMINUS C Amount: Cysteinyl vedotin 6603L01WUR
AMINO ACID REMOVAL [1_449] [2_449] C-TERMINUS K LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL