Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H6N4O2 |
Molecular Weight | 166.1374 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(=O)NC2=C(NC=N2)C1=O
InChI
InChIKey=MVOYJPOZRLFTCP-UHFFFAOYSA-N
InChI=1S/C6H6N4O2/c1-10-5(11)3-4(8-2-7-3)9-6(10)12/h2H,1H3,(H,7,8)(H,9,12)
Molecular Formula | C6H6N4O2 |
Molecular Weight | 166.1374 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | 1995 Nov 9 |
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Neurotoxic convulsions induced by theophylline and its metabolites in mice. | 1996 Jun |
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Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. | 2001 Dec |
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Exercise training improves insulin-mediated capillary recruitment in association with glucose uptake in rat hindlimb. | 2001 Dec |
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Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo. | 2002 Apr |
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Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. | 2002 Aug |
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Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. | 2002 Jan |
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T-1032, a cyclic GMP phosphodiesterase-5 inhibitor, acutely blocks physiologic insulin-mediated muscle haemodynamic effects and glucose uptake in vivo. | 2003 Dec |
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Nonnutritive flow impairs uptake of fatty acid by white muscles of the perfused rat hindlimb. | 2003 Mar |
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Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. | 2004 |
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Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study. | 2004 |
|
Insulin sensitivity of muscle capillary recruitment in vivo. | 2004 Feb |
|
Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine. | 2004 Jul 16 |
|
Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure. | 2004 Mar |
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Skeletal muscle contraction stimulates capillary recruitment and glucose uptake in insulin-resistant obese Zucker rats. | 2004 Oct |
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Capillary electrochromatography of caffeine and its metabolites in rat brain microdialysate. | 2005 Feb |
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Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls. | 2006 Dec |
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Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations. | 2006 Sep 28 |
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Theophylline and its metabolites produce a stimulating cholinergic effect on the small intestine and a nonadrenergic noncholinergic relaxing effect on the colon: a comparative study in the rabbit intestine. | 2007 Dec |
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Acute effects of wortmannin on insulin's hemodynamic and metabolic actions in vivo. | 2007 Mar |
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Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes. | 2008 |
|
Point: There is capillary recruitment in active skeletal muscle during exercise. | 2008 Mar |
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Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected? | 2009 Apr |
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Demethylation of theophylline (1,3-dimethylxanthine) to 1-methylxanthine: the first step of an antioxidising cascade. | 2010 |
|
Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance. | 2010 Sep |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:48:38 UTC 2023
by
admin
on
Fri Dec 15 17:48:38 UTC 2023
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Record UNII |
7EE8WCA32U
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Record Status |
Validated (UNII)
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Record Version |
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C053085
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7EE8WCA32U
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DTXSID30210271
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admin on Fri Dec 15 17:48:38 UTC 2023 , Edited by admin on Fri Dec 15 17:48:38 UTC 2023
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80220
Created by
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6136-37-4
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admin on Fri Dec 15 17:48:38 UTC 2023 , Edited by admin on Fri Dec 15 17:48:38 UTC 2023
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228-108-5
Created by
admin on Fri Dec 15 17:48:38 UTC 2023 , Edited by admin on Fri Dec 15 17:48:38 UTC 2023
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