Nerigliatin

CN(C)C(=O)C1=NC=C(OC2=C3C=C(C)OC3=CC(=C2)C(=O)NC4=NC=C(C)N=C4)C=N1

InChIKey=MASKQITXHVYVFL-UHFFFAOYSA-N

InChI=1S/C22H20N6O4/c1-12-8-24-19(11-23-12)27-21(29)14-6-17-16(5-13(2)31-17)18(7-14)32-15-9-25-20(26-10-15)22(30)28(3)4/h5-11H,1-4H3,(H,24,27,29)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Glucokinase 4 Target ID: P35557 Gene ID: 2645.0 Gene Symbol: GCK Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/23831135 \| https://adisinsight.springer.com/drugs/800031713 \| https://newdrugapprovals.org/tag/pf-04937319/	Activator 1430		0.19 µM [EC50]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:41:52 GMT 2023` Edited by `admin` on `Sat Dec 16 01:41:52 GMT 2023`
Record UNII	7E99B9ZM19
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

Nerigliatin

Common Name

English

PF-04937319

Code

English

2-Pyrimidinecarboxamide, N,N-dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-

Systematic Name

English

nerigliatin [INN]

Common Name

English

N,N-Dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB15009