Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C24H29NO.ClH |
Molecular Weight | 383.954 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.[H][C@]12C[C@](O)(CCN1C[C@]3([H])C4=C(CCC5=C3C2=CC=C5)C=CC=C4)C(C)C
InChI
InChIKey=LSZSZUUPKKTESX-GOXMAUIJSA-N
InChI=1S/C24H29NO.ClH/c1-16(2)24(26)12-13-25-15-21-19-8-4-3-6-17(19)10-11-18-7-5-9-20(23(18)21)22(25)14-24;/h3-9,16,21-22,26H,10-15H2,1-2H3;1H/t21-,22-,24-;/m1./s1
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C24H29NO |
Molecular Weight | 347.4932 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Dexclamol is a sedative agent. It was found to potentiate the anesthetic actions of halothane. In potentiating the effects of halothane, dexclamol behaved both qualitatively and quantitatively in a manner similar to droperidol. Dexclamol, however, was approximately 37 times less potent than droperidol in antagonizing the vasopressor effects of epinephrine. The neuroleptic agent (+)-dexclamol, but not (-)-dexclamol, affects central dopamine (DA) and norepinephrine (NE) turnover and indicates a stereochemical specificity with respect to antagonism of central DA and NE receptors. Dexclamol was as effective as droperidol at the same dose in inducing neurolepsy and in supplementing nitrous oxide anaesthesia. Changes in heart rate, respiratory rate and rectal temperature in the animals treated with dexclamol were not different from those observed in the animals treated with droperidol.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1023951
200 ng/kg
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:11:32 GMT 2023
by
admin
on
Fri Dec 15 15:11:32 GMT 2023
|
Record UNII |
7DWJ51V84C
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
CHEMBL320656
Created by
admin on Fri Dec 15 15:11:32 GMT 2023 , Edited by admin on Fri Dec 15 15:11:32 GMT 2023
|
PRIMARY | |||
|
52389-27-2
Created by
admin on Fri Dec 15 15:11:32 GMT 2023 , Edited by admin on Fri Dec 15 15:11:32 GMT 2023
|
PRIMARY | |||
|
7DWJ51V84C
Created by
admin on Fri Dec 15 15:11:32 GMT 2023 , Edited by admin on Fri Dec 15 15:11:32 GMT 2023
|
PRIMARY | |||
|
DTXSID40200401
Created by
admin on Fri Dec 15 15:11:32 GMT 2023 , Edited by admin on Fri Dec 15 15:11:32 GMT 2023
|
PRIMARY | |||
|
40342
Created by
admin on Fri Dec 15 15:11:32 GMT 2023 , Edited by admin on Fri Dec 15 15:11:32 GMT 2023
|
PRIMARY | |||
|
C167022
Created by
admin on Fri Dec 15 15:11:32 GMT 2023 , Edited by admin on Fri Dec 15 15:11:32 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |